CMAUP Plant Collective Molecular Activities

Plant Name: Xanthium canadense

Taxonomic Information:

Plant ID: NPO16481
Plant Latin Name: Xanthium canadense
Taxonomy Genus: Xanthium
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	HKDC1; USP2;
Oxidoreductase	MAOB;
Unclassified	MAPT; LMNA; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	HKDC1	Putative hexokinase HKDC1	Q2TB90	CHEMBL1741200
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0042053; regulation of dopamine metabolic process	6.866E-03	1.000E+00	MAOB
BP	GO:0009987; cellular process	GO:0008088; axo-dendritic transport	1.620E-02	1.000E+00	MAPT
BP	GO:0009987; cellular process	GO:0034605; cellular response to heat	1.620E-02	1.000E+00	MAPT
BP	GO:0009987; cellular process	GO:0007017; microtubule-based process	1.654E-02	1.000E+00	LMNA, MAPT
BP	GO:0009987; cellular process	GO:0051081; nuclear envelope disassembly	1.727E-02	1.000E+00	LMNA
CC	GO:0044464; cell part	GO:0005764; lysosome	4.017E-03	1.000E+00	NPC1, RAB9A
CC	GO:0044464; cell part	GO:0030673; axolemma	5.785E-03	1.000E+00	MAPT
CC	GO:0043226; organelle	GO:0016607; nuclear speck	7.173E-03	1.000E+00	LMNA, MAPT
MF	GO:0003824; catalytic activity	GO:0008131; primary amine oxidase activity	2.173E-03	1.000E+00	MAOB
MF	GO:0005488; binding	GO:0034452; dynactin binding	3.980E-03	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0034185; apolipoprotein binding	5.785E-03	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0036094; small molecule binding	6.434E-03	1.000E+00	HKDC1, MAOB, NPC1, RAB9A
MF	GO:0005488; binding	GO:0019903; protein phosphatase binding	4.199E-02	1.000E+00	MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases