CMAUP Plant Collective Molecular Activities

Plant Name: Serratula strangulata

Taxonomic Information:

Plant ID: NPO16416
Plant Latin Name: Serratula strangulata
Taxonomy Genus: Serratula
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 324596
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	EGFR;
Lyase	CA1; CA5B; CA5A; CA6; CA12; CA9;
Nuclear hormone receptor subfamily 1 group A	THRB;
Lysine demethylase	KDM4E;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.240E-14	1.350E-10	CA1, CA12, CA5A, CA5B, CA6, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.486E-14	3.256E-10	CA1, CA12, CA5A, CA5B, CA6, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.492E-08	1.571E-04	CA1, CA12, CA5A, CA5B, CA6, CA9, THRB
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	8.842E-07	1.605E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	4.417E-06	5.658E-03	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.201E-17	6.971E-13	CA1, CA12, CA5A, CA5B, CA6, CA9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.940E-05	2.223E-02	CYP2D6, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.422E-17	2.954E-15	CA12, CA1, CA5B, CA5A, CA6, CA9
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.323E-04	1.085E-02	CYP2D6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.075E-04	1.085E-02	CYP2D6, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.584E-02	9.771E-02	CYP3A4
Unclassified	Unclassified	hsa04320	Dorso-ventral axis formation	1.475E-02	9.771E-02	EGFR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.837E-02	9.771E-02	CYP3A4
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	4.789E-02	9.771E-02	EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	5.314E-02	9.771E-02	EGFR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	4.736E-02	9.771E-02	EGFR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.420E-02	9.771E-02	CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases