CMAUP Plant Collective Molecular Activities

Plant Name: Chenopodium album

Taxonomic Information:

Plant ID: NPO16333
Plant Latin Name: Chenopodium album
Taxonomy Genus: Chenopodium
Taxonomy Family: Chenopodiaceae

Plant External Links:

NCBI TaxonomyDB: 3559
Plant-of-the-World-Online: 55993-2

Used in Medicines:

Country/Region:

Pakistan; Madagascar; Italy; South Africa; India; Lebanon; Zimbabwe; Swaziland; Angola; New Zealand

Traditional Medicine System:

Medicinal Functions:

Anthelmintic; Antiphlogistic; Antirheumatic; Contraceptive; Laxative; Odontalgic

Geographical Distribution:

Brazil; Canada; Madagascar; Italy; Bangladesh; Kenya; Lebanon; Nepal; France; Bahamas; Ethiopia; Norway; Netherlands; Ireland; Austria; Swaziland; Bolivia; Cameroon; Ecuador; Turkmenistan; Uzbekistan; Belarus; Algeria; Cuba; Iceland; Zambia; Cape Verde; United States; Zimbabwe; China; Chile; Belgium; Germany; Dominican Republic; Kazakhstan; Spain; Ukraine; Mauritania; Georgia; Libya; Denmark; Poland; Finland; New Caledonia; Turkey; Mauritius; Morocco; Sweden; Seychelles; Namibia; Japan; Switzerland; New Zealand; Russia; Bulgaria; Pakistan; Romania; Albania; Angola; Portugal; Mexico; Egypt; Tajikistan; South Africa; India; Peru; United Kingdom; Lesotho; Djibouti; Mozambique; Tunisia; Colombia; Greece; Sri Lanka; Hungary; Taiwan; Cyprus; Botswana

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Peptide receptor (family A GPCR)	NMUR2;
Hydrolase	GAA; ACHE;
Protein Kinase	MAPK1;
Enzyme_unclassified	POLB;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	6.752E-07	4.575E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	6.752E-07	4.575E-03	ADRA2A, ADRA2C
BP	GO:0032501; multicellular organismal process	GO:0006940; regulation of smooth muscle contraction	1.261E-06	4.575E-03	ADRA2A, ADRA2C, NMUR2
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	3.377E-07	4.575E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	3.149E-06	7.618E-03	ADRA2A, ADRA2C
MF	GO:0005488; binding	GO:0051379; epinephrine binding	3.149E-06	7.618E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0030168; platelet activation	6.186E-06	1.225E-02	ADRA2A, ADRA2C, MAPK1
MF	GO:0003824; catalytic activity	GO:0004574; oligo-1,6-glucosidase activity	7.247E-04	1.962E-01	GAA
CC	GO:0016020; membrane	GO:0005886; plasma membrane	7.872E-04	2.065E-01	ACHE, ADRA2A, ADRA2C, GAA, MAPK1, NMUR2
CC	GO:0044464; cell part	GO:0030424; axon	3.543E-03	4.691E-01	ADRA2C, MAPK1
CC	Unclassified;	GO:0031143; pseudopodium	6.145E-03	6.055E-01	MAPK1
CC	GO:0044464; cell part	GO:0032839; dendrite cytoplasm	9.026E-03	7.473E-01	MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.953E-05	1.836E-03	MAPK1, ADRA2C, ADRA2A
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8.828E-05	4.149E-03	NMUR2, ADRA2C, ADRA2A
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	6.295E-04	1.972E-02	ACHE, MAPK1
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	2.122E-03	4.988E-02	POLB, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	2.116E-02	6.113E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	2.150E-02	6.113E-02	MAPK1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.978E-02	6.113E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	2.288E-02	6.113E-02	MAPK1
09150 Organismal Systems	09151 Immune system	hsa04664	Fc epsilon RI signaling pathway	2.356E-02	6.113E-02	MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	2.288E-02	6.113E-02	MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases