Plant Name: Clematis terniflora var. mandshurica
Taxonomic Information:
Plant ID: NPO16314.1
Plant Latin Name: Clematis terniflora var. mandshurica
Taxonomy Genus: Clematis
Taxonomy Family: Ranunculaceae
Plant External Links:
NCBI TaxonomyDB:
231663
Plant-of-the-World-Online:
710123-1
Used in Medicines:
Unknown.
Geographical Distribution:
United States; Japan; New Zealand; China; South Africa
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| TSHR; | |
| PTPN1; PTPN2; ACP1; PTPRF; | |
| RECQL; HSD11B1; GFER; HSD17B10; AKR1B10; ALDH1A1; UBE2N; | |
| CA12; CA9; CA7; | |
| PPARA; PPARD; | |
| RORC; | |
| NR1H4; | |
| CASP1; CASP7; | |
| TLR2; | |
| HTT; FABP3; FABP2; FABP4; FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | UBE2N | Ubiquitin-conjugating enzyme E2 N | P61088 | CHEMBL6089 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | P24666 | CHEMBL4903 |
| Protein Phosphatase | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | P10586 | CHEMBL3521 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 5.845E-08 | 2.545E-04 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 8.671E-07 | 1.154E-03 | CYP19A1, NR1H4, PPARA, PPARD, PTPN2 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 9.540E-07 | 1.154E-03 | NR1H4, PPARA, PPARD, RORC |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.519E-06 | 1.741E-03 | CA12, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 1.889E-06 | 1.985E-03 | AKR1B10, CYP19A1, CYP1A2, HSD11B1, NR1H4, PPARD |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 2.027E-06 | 2.006E-03 | NR1H4, PPARA, PPARD, RORC |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 6.837E-06 | 4.909E-03 | NR1H4, PPARA, PPARD, RORC, UBE2N |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 6.989E-06 | 4.909E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 6.989E-06 | 4.909E-03 | GPBAR1, NR1H4 |
| BP | GO:0050896; response to stimulus | GO:0033993; response to lipid | 1.033E-05 | 6.348E-03 | CA9, CASP1, CYP1A2, FABP3, NR1H4, PPARD, RORC, TLR2 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 1.396E-05 | 7.985E-03 | PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 1.606E-05 | 8.529E-03 | ACP1, PTPN1, PTPN2, PTPRF |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.440E-05 | 1.155E-02 | CA12, CA7, CA9, NR1H4, PPARA, PPARD, PTPN1, RORC |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 7.510E-10 | 4.807E-08 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 2.042E-06 | 6.534E-05 | CA12, CA7, CA9 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 7.580E-05 | 1.422E-03 | CASP7, CASP1, TLR2 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 8.888E-05 | 1.422E-03 | HSD11B1, CYP1A2, CYP19A1 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.837E-04 | 2.352E-03 | PTPN1, ACP1, PTPRF |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 5.743E-04 | 6.126E-03 | PTPN1, PPARA, PTPRF |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 3.185E-03 | 2.912E-02 | FABP4, TSHR |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 4.266E-03 | 3.034E-02 | RORC, TLR2 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 4.266E-03 | 3.034E-02 | CYP1A2, ALDH1A1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 5.639E-03 | 3.281E-02 | CASP7, CASP1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
