CMAUP Plant Collective Molecular Activities

Plant Name: Marrubium supinum

Taxonomic Information:

Plant ID: NPO16289
Plant Latin Name: Marrubium supinum
Taxonomy Genus: Marrubium
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 155230
Plant-of-the-World-Online: 449975-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Tunisia; Morocco; China; Spain; Algeria

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD3;
Enzyme_unclassified	ALPL;
Protein Kinase	SRC; IGF1R; PTK2; AXL; MAPK1; ALK; KDR;
Lyase	CA2; CA14;
Transcription Factor	NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Protein Kinase	SRC	Tyrosine-protein kinase SRC	P12931	CHEMBL267
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	PTK2	Focal adhesion kinase 1	Q05397	CHEMBL2695
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	ALK	ALK tyrosine kinase receptor	Q9UM73	CHEMBL4247
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	1.501E-08	4.669E-05	IGF1R, KDR, PTK2, SRC
MF	GO:0060089; molecular transducer activity	GO:0004714; transmembrane receptor protein tyrosine kinase activity	4.671E-08	7.824E-05	ALK, AXL, IGF1R, KDR
BP	GO:0009987; cellular process	GO:0048010; vascular endothelial growth factor receptor signaling pathway	8.586E-08	1.169E-04	AXL, KDR, PTK2, SRC
BP	GO:0009987; cellular process	GO:0035690; cellular response to drug	4.662E-07	4.230E-04	AXL, KDR, MAPK1, NFKB1, SRC
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	4.254E-06	2.370E-03	IGF1R, KDR, MAPK1, PTK2, SRC
BP	GO:0022610; biological adhesion	GO:0051893; regulation of focal adhesion assembly	4.463E-06	2.370E-03	KDR, PTK2, SRC
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	5.281E-06	2.613E-03	AXL, CA2, KDR, MAPK1, SRC
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	6.043E-06	2.633E-03	CA2, DRD3, KDR, SRC
MF	GO:0005488; binding	GO:0005524; ATP binding	8.470E-06	3.236E-03	ALK, AXL, IGF1R, KDR, MAPK1, PTK2, SRC
BP	GO:0002376; immune system process	GO:0002684; positive regulation of immune system process	1.425E-05	4.371E-03	AXL, CA2, MAPK1, NFKB1, PTK2, SRC
BP	GO:0009987; cellular process	GO:0060159; regulation of dopamine receptor signaling pathway	1.588E-05	4.736E-03	ALK, DRD3
BP	GO:0009987; cellular process	GO:0038127; ERBB signaling pathway	1.637E-05	4.816E-03	MAPK1, PTK2, SRC
BP	GO:0009987; cellular process	GO:0045595; regulation of cell differentiation	2.193E-05	5.824E-03	AXL, CA2, DRD3, KDR, MAPK1, NFKB1, PTK2
BP	GO:0050896; response to stimulus	GO:0038166; angiotensin-activated signaling pathway	2.327E-05	6.032E-03	CA2, SRC
BP	GO:0009987; cellular process	GO:0014066; regulation of phosphatidylinositol 3-kinase signaling	2.614E-05	6.467E-03	KDR, MAPK1, PTK2
BP	GO:0050896; response to stimulus	GO:0034614; cellular response to reactive oxygen species	3.605E-05	8.198E-03	AXL, MAPK1, SRC
BP	GO:0032502; developmental process	GO:0048513; animal organ development	3.614E-05	8.198E-03	AXL, CA2, KDR, MAPK1, PTK2, SRC
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.698E-05	8.302E-03	CA14, CA2
BP	GO:0009987; cellular process	GO:0030168; platelet activation	3.808E-05	8.345E-03	AXL, MAPK1, SRC
BP	GO:0009987; cellular process	GO:2000811; negative regulation of anoikis	4.225E-05	8.762E-03	PTK2, SRC
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	4.728E-05	9.532E-03	ALPL, MAPK1, NFKB1, SRC
BP	GO:0051179; localization	GO:2000641; regulation of early endosome to late endosome transport	4.787E-05	9.534E-03	MAPK1, SRC
BP	GO:0050896; response to stimulus	GO:0071222; cellular response to lipopolysaccharide	4.816E-05	9.534E-03	AXL, NFKB1, SRC
BP	GO:0009987; cellular process	GO:0097237; cellular response to toxic substance	4.938E-05	9.687E-03	AXL, KDR, NFKB1
MF	Unclassified;	GO:0005057; signal transducer activity, downstream of receptor	5.188E-05	9.997E-03	ALK, KDR, MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	3.806E-08	3.168E-06	SRC, KDR, MAPK1, PTK2
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	7.666E-08	3.168E-06	SRC, KDR, MAPK1, PTK2, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	7.479E-08	3.168E-06	SRC, KDR, MAPK1, PTK2, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.004E-06	3.114E-05	KDR, MAPK1, PTK2, NFKB1, IGF1R
09150 Organismal Systems	09151 Immune system	hsa04062	Chemokine signaling pathway	3.455E-06	8.568E-05	SRC, MAPK1, NFKB1, PTK2
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	5.578E-06	1.153E-04	SRC, KDR, MAPK1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	7.449E-06	1.155E-04	KDR, MAPK1, NFKB1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	9.615E-06	1.295E-04	SRC, MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	7.059E-06	1.155E-04	SRC, MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.820E-05	1.881E-04	MAPK1, NFKB1, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.044E-05	1.295E-04	SRC, MAPK1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	1.700E-05	1.881E-04	SRC, MAPK1, PTK2
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	6.672E-05	5.516E-04	MAPK1, NFKB1, PTK2, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.822E-05	2.691E-04	MAPK1, NFKB1, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	7.989E-05	6.191E-04	SRC, MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	2.181E-04	1.423E-03	SRC, MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05152	Tuberculosis	1.437E-04	1.024E-03	SRC, MAPK1, NFKB1
09140 Cellular Processes	09142 Cell motility	hsa04810	Regulation of actin cytoskeleton	2.475E-04	1.534E-03	SRC, MAPK1, PTK2
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.486E-04	1.024E-03	NFKB1, PTK2, IGF1R
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	4.331E-04	2.441E-03	SRC, KDR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	4.992E-04	2.565E-03	ALK, MAPK1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	5.171E-04	2.565E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	6.722E-04	3.069E-03	MAPK1, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	5.729E-04	2.732E-03	MAPK1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	6.929E-04	3.069E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.671E-04	1.577E-03	SRC, MAPK1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	8.470E-04	3.183E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	8.014E-04	3.183E-03	MAPK1, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7.354E-04	3.145E-03	SRC, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	8.470E-04	3.183E-03	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	5.171E-04	2.565E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	8.470E-04	3.183E-03	MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	1.312E-03	4.171E-03	SRC, MAPK1
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.173E-03	3.931E-03	NFKB1, PTK2
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.612E-03	4.544E-03	MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.519E-03	4.544E-03	MAPK1, IGF1R
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.399E-03	4.337E-03	NFKB1, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05100	Bacterial invasion of epithelial cells	9.662E-04	3.423E-03	SRC, PTK2
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.550E-03	4.544E-03	SRC, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	8.938E-04	3.260E-03	MAPK1, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	1.228E-03	4.006E-03	SRC, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	1.581E-03	4.544E-03	NFKB1, PTK2
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	1.173E-03	3.931E-03	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	1.708E-03	4.605E-03	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	1.774E-03	4.680E-03	MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.908E-03	4.930E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	1.708E-03	4.605E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	2.192E-03	5.402E-03	MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.192E-03	5.402E-03	SRC, MAPK1
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	2.340E-03	5.461E-03	SRC, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	2.265E-03	5.402E-03	MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	2.265E-03	5.402E-03	MAPK1, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	2.378E-03	5.461E-03	MAPK1, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.067E-03	6.445E-03	MAPK1, NFKB1
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	2.732E-03	5.929E-03	MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	2.773E-03	5.929E-03	MAPK1, IGF1R
09150 Organismal Systems	09158 Development	hsa04360	Axon guidance	2.533E-03	5.710E-03	MAPK1, PTK2
09150 Organismal Systems	09152 Endocrine system	hsa04921	Oxytocin signaling pathway	3.886E-03	7.899E-03	SRC, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	2.773E-03	5.929E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05164	Influenza A	4.743E-03	9.486E-03	MAPK1, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3.153E-03	6.517E-03	MAPK1, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.466E-05	3.955E-04	CA2, CA14

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Mesothelioma	C45	PTK2;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Brain cancer	C71, D33	SRC;
C00-D49: Neoplasms	Breast cancer	C50	IGF1R; KDR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3;
C00-D49: Neoplasms	Cancer	C00-C96	PTK2; IGF1R; KDR; NFKB1; MAPK1; SRC;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	SRC;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	SRC;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	PTK2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD3;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Osteosarcoma	C40-C41	SRC;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Chronic myelogenous leukaemia	C92.1	SRC;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD3;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	SRC;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	AML	NA	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	IGF1R; KDR; AXL;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	SRC;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; SRC;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	PTK2; IGF1R; KDR; MAPK1; SRC;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
C00-D49: Neoplasms	Advanced breast cancer	C50	SRC;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD3;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	IGF1R; KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases