CMAUP Plant Collective Molecular Activities

Plant Name: Malus pumila

Taxonomic Information:

Plant ID: NPO16230
Plant Latin Name: Malus pumila
Taxonomy Genus: Malus
Taxonomy Family: Rosaceae

Plant External Links:

NCBI TaxonomyDB: 283210
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Italy; China; India

Traditional Medicine System:

Sowa-Rigpa; TCM; Unani; Ayurveda; Siddha

Medicinal Functions:

Anthelmintic; Antibacterial; Bach; Hypnotic; Refrigerant

Geographical Distribution:

India; Italy; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; RECQL; ALDH1A1; BRCA1;
Metallo protease	MMP2; MMP9; MMP1;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	3.011E-06	3.058E-02	MMP1, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	5.434E-06	3.058E-02	MMP1, MMP2, MMP9
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	7.021E-06	3.058E-02	MMP1, MMP2, MMP9
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	1.317E-05	4.781E-02	MMP1, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	1.682E-05	5.233E-02	MMP1, MMP2, MMP9
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	2.941E-05	8.006E-02	SLCO1B1, SLCO1B3
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	4.436E-05	1.073E-01	MMP2, MMP9
BP	GO:0009987; cellular process	GO:0006302; double-strand break repair	5.507E-05	1.090E-01	BRCA1, RECQL, TDP1
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	5.298E-05	1.090E-01	SLCO1B1, SLCO1B3
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	7.249E-05	1.153E-01	SLCO1B1, SLCO1B3
MF	GO:0003824; catalytic activity	GO:0004252; serine-type endopeptidase activity	1.659E-04	2.007E-01	MMP1, MMP2, MMP9
CC	GO:0044421; extracellular region part	GO:0005578; proteinaceous extracellular matrix	2.373E-04	2.318E-01	MMP1, MMP2, MMP9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	3.313E-04	2.774E-01	BRCA1, MMP1, MMP2, MMP9
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.176E-03	9.424E-01	SLCO1B1, SLCO1B3
CC	GO:0016020; membrane	GO:0005886; plasma membrane	3.365E-02	1.000E+00	BRCA1, MMP2, SLCO1B1, SLCO1B3, TDP1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	6.660E-07	1.265E-05	MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.965E-04	3.778E-03	MMP1, MMP2, MMP9
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.402E-04	3.778E-03	SLCO1B1, SLCO1B3
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	8.537E-04	4.055E-03	MMP2, MMP9
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	1.209E-03	4.596E-03	MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	3.521E-03	1.115E-02	MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	7.385E-03	2.005E-02	BRCA1, MMP9
09120 Genetic Information Processing	09124 Replication and repair	hsa03460	Fanconi anemia pathway	2.360E-02	5.606E-02	BRCA1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.888E-02	5.820E-02	ALDH1A1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.063E-02	5.820E-02	MMP1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
C00-D49: Neoplasms	Cancer	C00-C96	MMP9; MMP2;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; MMP2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases