Plant Name: Glycyrrhiza sp.
Taxonomic Information:
Plant ID: NPO16193
Plant Latin Name: Glycyrrhiza sp.
Taxonomy Genus: Glycyrrhiza
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2C19; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Enrichment of Gene Ontology of Target Proteins (Activity≤)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 3.106E-04 | 1.000E+00 | CYP2C19 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 5.177E-04 | 1.000E+00 | CYP2C19 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 6.212E-04 | 1.000E+00 | CYP2C19 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.087E-03 | 1.000E+00 | CYP2C19 |
| BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 5.902E-03 | 1.000E+00 | CYP2C19 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 1.279E-02 | 1.000E+00 | CYP2C19 |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 4.649E-02 | 1.000E+00 | CYP2C19 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 4.768E-02 | 1.000E+00 | CYP2C19 |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 8.801E-04 | 1.000E+00 | CYP2C19 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 1.760E-03 | 1.000E+00 | CYP2C19 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 2.330E-03 | 1.000E+00 | CYP2C19 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 6.627E-03 | 1.000E+00 | CYP2C19 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 8.283E-03 | 1.000E+00 | CYP2C19 |
Enriched KEGG Pathways of Target Proteins (Activity≤)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.450E-03 | 6.150E-03 | CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 3.100E-03 | 6.150E-03 | CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 3.450E-03 | 6.150E-03 | CYP2C19 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 5.600E-03 | 6.720E-03 | CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 4.100E-03 | 6.150E-03 | CYP2C19 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 6.195E-02 | 6.195E-02 | CYP2C19 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
