Plant Name: Vitex peduncularis
Taxonomic Information:
Plant ID: NPO16126
Plant Latin Name: Vitex peduncularis
Taxonomy Genus: Vitex
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
1489957
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Thailand; IndiaTraditional Medicine System:
Geographical Distribution:
Thailand; India
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:1901529; positive regulation of anion channel activity | 4.141E-04 | 9.018E-01 | ABCB1 |
| BP | GO:0050896; response to stimulus | GO:0047484; regulation of response to osmotic stress | 9.317E-04 | 9.392E-01 | ABCB1 |
| BP | GO:0051179; localization | GO:2001225; regulation of chloride transport | 1.035E-03 | 9.392E-01 | ABCB1 |
| BP | GO:0051179; localization | GO:0042908; xenobiotic transport | 1.035E-03 | 9.392E-01 | ABCB1 |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 8.282E-04 | 9.392E-01 | ALOX5 |
| MF | GO:0005215; transporter activity | GO:0008559; xenobiotic transmembrane transporting ATPase activity | 7.247E-04 | 9.392E-01 | ABCB1 |
| CC | GO:0044464; cell part | GO:0034774; secretory granule lumen | 3.296E-02 | 1.000E+00 | ALOX5 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 4.994E-03 | 1.418E-02 | ALOX5 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 6.191E-03 | 1.418E-02 | ALOX5 |
| 09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 4.395E-03 | 1.418E-02 | ABCB1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 7.088E-03 | 1.418E-02 | ABCB1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.117E-02 | 1.569E-02 | ALOX5 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 1.177E-02 | 1.569E-02 | ALOX5 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 2.948E-02 | 3.369E-02 | ABCB1 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.201E-01 | 1.201E-01 | ALOX5 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | ALOX5; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ALOX5; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | ALOX5; |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5; |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | ALOX5; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | ALOX5; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | ALOX5; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | ALOX5; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | ALOX5; |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | ALOX5; |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | ALOX5; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | ALOX5; |
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | ALOX5; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | ALOX5; |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | ALOX5; |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | ALOX5; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | ALOX5; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
