CMAUP Plant Collective Molecular Activities

Plant Name: Swertia decora

Plant ID: NPO16120
Plant Latin Name: Swertia decora
Taxonomy Genus: Swertia
Taxonomy Family: Gentianaceae

NCBI TaxonomyDB: 166616
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA13; CA12; CA9;
Oxidoreductase	MAOA;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.515E-09	3.298E-05	CA12, CA13, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.375E-08	2.586E-04	CA12, CA13, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.404E-08	3.197E-04	CA12, CA13, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.878E-04	6.964E-01	CA12, CA13, CA9
BP	GO:0065007; biological regulation	GO:0055081; anion homeostasis	8.464E-03	1.000E+00	CA12
BP	GO:0008152; metabolic process	GO:0006584; catecholamine metabolic process	8.876E-03	1.000E+00	MAOA
BP	GO:0009987; cellular process	GO:0043620; regulation of DNA-templated transcription in response to stress	2.421E-02	1.000E+00	CA9
BP	GO:0051179; localization	GO:0006810; transport	3.171E-02	1.000E+00	CA12, CA13, CA9
CC	GO:0044464; cell part	GO:0043209; myelin sheath	3.010E-02	1.000E+00	CA13
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.797E-02	1.000E+00	CA9
MF	GO:0003824; catalytic activity	GO:0008131; primary amine oxidase activity	1.242E-03	1.000E+00	MAOA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.039E-09	2.855E-08	CA12, CA9, CA13
09100 Metabolism	09105 Amino acid metabolism	hsa00340	Histidine metabolism	4.792E-03	1.744E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	3.396E-03	1.744E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	6.982E-03	1.744E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	7.977E-03	1.744E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7.977E-03	1.744E-02	MAOA
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	9.765E-03	1.744E-02	MAOA
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	1.333E-02	1.922E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00330	Arginine and proline metabolism	9.963E-03	1.744E-02	MAOA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.373E-02	1.922E-02	MAOA

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases