CMAUP Plant Collective Molecular Activities

Plant Name: Niphogeton ternata

Taxonomic Information:

Plant ID: NPO16027
Plant Latin Name: Niphogeton ternata
Taxonomy Genus: Niphogeton
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 681593
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A13; CYP1A2; CYP2D6; CYP2A6; CYP3A4; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.810E-13	1.971E-09	CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	6.931E-13	3.773E-09	CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	2.084E-12	9.076E-09	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.039E-12	1.026E-08	CYP1A2, CYP2A13, CYP2C19, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	5.968E-12	1.607E-08	CYP1A2, CYP2A6, CYP2C19, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	8.120E-12	1.607E-08	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.205E-11	1.307E-07	CYP1A2, CYP2A13, CYP2A6, CYP2C19
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.128E-10	1.754E-07	CYP1A2, CYP2A6, CYP2C19, CYP2D6, CYP3A4, NR1H4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.066E-10	1.754E-07	CYP1A2, CYP2A13, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.619E-10	4.148E-07	CYP1A2, CYP2A13, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	1.631E-09	1.614E-06	CYP2A13, CYP2A6, CYP2D6
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.024E-08	7.964E-06	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	3.162E-08	2.152E-05	CYP2A13, CYP2A6, CYP2C19
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	1.501E-07	8.833E-05	CYP2A13, CYP2A6
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	2.982E-07	1.623E-04	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.502E-07	2.228E-04	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	9.002E-07	4.171E-04	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.743E-06	2.879E-03	CYP1A2, CYP2C19
CC	GO:0016020; membrane	GO:0031090; organelle membrane	1.667E-04	5.763E-02	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
CC	Unclassified;	GO:0031143; pseudopodium	7.020E-03	7.962E-01	MAPK1
CC	GO:0044464; cell part	GO:0035578; azurophil granule lumen	3.708E-02	1.000E+00	MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.342E-11	1.533E-09	CYP2A6, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.129E-11	1.533E-09	CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.678E-11	1.855E-09	CYP2A6, CYP2A13, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.527E-07	3.742E-06	CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.814E-06	2.962E-05	CYP2A6, CYP1A2, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	9.380E-06	1.313E-04	CYP2D6, MAPK1, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.436E-04	1.760E-03	CYP2A6, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	8.386E-04	7.471E-03	CYP2A6, CYP1A2, CYP2C19, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.289E-04	2.492E-03	CYP1A2, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.431E-04	3.363E-03	NR1H4, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.399E-06	2.742E-05	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases