CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Enzyme_unclassified	TDP1; HSD11B1; HSD17B10; POLB; APEX1;
Protein Kinase	MAPK1;
Lyase	CA12;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Toll-like and Il-1 receptors	TLR2;
Unclassified	MAPT; HTT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163

Showing 1 to 10 of 12 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	3.538E-07	7.704E-03	APEX1, POLB
BP	GO:0007610; behavior	GO:0007611; learning or memory	9.791E-06	3.752E-02	HTT, MAPK1, MAPT, TLR2
MF	GO:0005488; binding	GO:0019902; phosphatase binding	2.352E-06	1.707E-02	MAPK1, MAPT, PPARA, PTPN1
MF	GO:0005488; binding	GO:0034452; dynactin binding	1.940E-05	4.224E-02	HTT, MAPT

Showing 1 to 4 of 4 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.725E-04	9.313E-03	POLB, APEX1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	8.702E-04	2.350E-02	PTPN1, MAPK1
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	1.774E-03	2.892E-02	MAPK1, TLR2
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	3.024E-03	3.266E-02	PTPN1, MAPK1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.211E-04	9.313E-03	MAPK1, MAPT, HSD17B10
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	8.470E-04	2.350E-02	MAPK1, TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	1.708E-03	2.892E-02	MAPK1, TLR2
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.874E-03	2.892E-02	PTPN1, PPARA
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	2.192E-03	2.959E-02	MAPK1, TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	2.773E-03	3.266E-02	MAPK1, PPARA

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;

Showing 1 to 10 of 14 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Isodon japonica var. glaucocalyx

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities