Plant Name: Isodon wikstroemioides
Taxonomic Information:
Plant ID: NPO15942
Plant Latin Name: Isodon wikstroemioides
Taxonomy Genus: Isodon
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
662930
Plant-of-the-World-Online:
915171-1
Used in Medicines:
Unknown.
Geographical Distribution:
China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| BCHE; ACHE; | |
| HIF1A; | |
| SMN1;SMN2; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Hydrolase | BCHE | Butyrylcholinesterase | P06276 | CHEMBL1914 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0009820; alkaloid metabolic process | 1.019E-09 | 2.220E-05 | BCHE, CYP1A2, CYP2D6 |
| MF | GO:0003824; catalytic activity | GO:0003990; acetylcholinesterase activity | 1.126E-07 | 1.226E-03 | ACHE, BCHE |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.687E-06 | 9.186E-03 | CYP1A2, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0042737; drug catabolic process | 6.888E-06 | 2.307E-02 | ACHE, CYP1A2, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 6.888E-06 | 2.307E-02 | BCHE, CYP1A2, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 7.417E-06 | 2.307E-02 | CYP1A2, CYP2D6 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 2.838E-05 | 6.866E-02 | CYP1A2, CYP2D6 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.106E-04 | 2.190E-01 | CYP1A2, CYP2D6 |
| MF | GO:0005488; binding | GO:0042165; neurotransmitter binding | 1.480E-04 | 2.479E-01 | ACHE, BCHE |
| BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 1.597E-04 | 2.483E-01 | CYP1A2, CYP2D6 |
| MF | GO:0005488; binding | GO:0001540; amyloid-beta binding | 1.973E-04 | 2.685E-01 | ACHE, BCHE |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 2.896E-03 | 6.370E-01 | BCHE |
| CC | GO:0043226; organelle | GO:0016607; nuclear speck | 7.173E-03 | 8.941E-01 | HIF1A, LMNA |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 4.065E-02 | 1.000E+00 | CYP1A2, CYP2D6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 2.436E-04 | 3.272E-03 | CYP2D6, CYP1A2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.727E-04 | 3.272E-03 | CYP2D6, CYP1A2 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 1.749E-03 | 1.399E-02 | CYP1A2 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 2.322E-02 | 4.870E-02 | HIF1A |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 2.562E-02 | 4.870E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 3.108E-02 | 4.870E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 2.870E-02 | 4.870E-02 | LMNA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 3.821E-02 | 4.870E-02 | ACHE |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 3.550E-02 | 4.870E-02 | HIF1A |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00564 | Glycerophospholipid metabolism | 3.278E-02 | 4.870E-02 | ACHE |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ACHE; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE; |
| C00-D49: Neoplasms | Cancer | C00-C96 | ACHE; |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE; |
| NA: NA | Upper abdominal bloating | NA | ACHE; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE; |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE; |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
