CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Lyase	CA2; CA3; CA14; CA7; CA5A; CA6; CA12; CA9; CA1; CA13;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912

Showing 1 to 10 of 13 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.553E-25	3.868E-21	CA1, CA12, CA13, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.254E-06	1.437E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.505E-23	3.541E-19	CA1, CA12, CA13, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	1.876E-05	1.776E-02	CA2, CA7
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	2.292E-05	2.079E-02	PPARA, PPARD
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.966E-14	1.202E-10	CA1, CA12, CA13, CA2, CA3, CA5A, CA6, CA7, CA9, PPARA, PPARD
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.317E-31	9.401E-27	CA1, CA12, CA13, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	6.262E-06	6.494E-03	CA1, CA2

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.974E-30	3.947E-29	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14, CA13
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	7.149E-03	4.766E-02	PPARA, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	8.928E-04	8.928E-03	PPARA, PPARD
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	1.741E-02	6.965E-02	CA2
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.485E-02	6.965E-02	CA2
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3.581E-02	7.843E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	4.519E-02	7.843E-02	TSHR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.519E-02	7.843E-02	CA2
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.643E-02	7.843E-02	PPARD
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	3.392E-02	7.843E-02	TSHR

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CA1;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1;

Showing 1 to 4 of 4 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Citrullus colocynthis

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities