Plant Name: Skimmia wallichii
Taxonomic Information:
Plant ID: NPO15864
Plant Latin Name: Skimmia wallichii
Taxonomy Genus: Skimmia
Taxonomy Family: Rutaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PTGES; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019371; cyclooxygenase pathway | 5.695E-04 | 1.000E+00 | PTGES |
| BP | GO:0050896; response to stimulus | GO:0032496; response to lipopolysaccharide | 1.434E-02 | 1.000E+00 | PTGES |
| BP | GO:0050896; response to stimulus | GO:0034097; response to cytokine | 2.475E-02 | 1.000E+00 | PTGES |
| BP | GO:0008283; cell proliferation | GO:0008285; negative regulation of cell proliferation | 3.645E-02 | 1.000E+00 | PTGES |
| BP | GO:0050896; response to stimulus | GO:0014070; response to organic cyclic compound | 3.764E-02 | 1.000E+00 | PTGES |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 4.142E-04 | 1.000E+00 | PTGES |
| CC | GO:0044464; cell part | GO:0048471; perinuclear region of cytoplasm | 3.350E-02 | 1.000E+00 | PTGES |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 4.768E-02 | 1.000E+00 | PTGES |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 3.100E-03 | 6.200E-03 | PTGES |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 6.195E-02 | 6.195E-02 | PTGES |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
