CMAUP Plant Collective Molecular Activities

Plant Name: Veratrum nigrum

Taxonomic Information:

Plant ID: NPO15848
Plant Latin Name: Veratrum nigrum
Taxonomy Genus: Veratrum
Taxonomy Family: Melanthiaceae

Plant External Links:

NCBI TaxonomyDB: 203100
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; Italy

Traditional Medicine System:

TCM

Medicinal Functions:

Analgesic; Anthelmintic; Emetic; Errhine; Expectorant; Laxative; Vermifuge

Geographical Distribution:

Italy; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1; TSHR;
Transcription Factor	TP53;
Plant homeodomain	KMT2A;
Bromodomain	CREBBP;
SLC superfamily of solute carriers	SLC22A3;
Unclassified	GMNN; MITF; PAX8; THPO; LMNA; SHH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP3A4; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	CREBBP	CREB-binding protein	Q92793	CHEMBL5747
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
SLC superfamily of solute carriers	SLC22A3	Solute carrier family 22 member 3	O75751	CHEMBL2073673
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	GMNN	Geminin	O75496	CHEMBL1293278
Unclassified	MITF	Microphthalmia-associated transcription factor	O75030	CHEMBL1741165
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	SHH	Sonic hedgehog protein	Q15465	CHEMBL5602

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.312E-09	2.028E-04	CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.021E-07	1.112E-03	CYP2C9, CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0038194; thyroid-stimulating hormone signaling pathway	6.433E-07	3.272E-03	PAX8, TSHR
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	6.433E-07	3.272E-03	PAX8, TSHR
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	7.514E-07	3.272E-03	CREBBP, CYP2C9, CYP2D6, CYP3A4, KMT2A, PTPN1, SHH, TP53
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.929E-06	6.000E-03	CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0001046; core promoter sequence-specific DNA binding	1.847E-06	6.000E-03	KMT2A, MITF, PAX8, TP53
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.747E-06	7.477E-03	CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.856E-06	8.396E-03	CYP2C9, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.096E-05	6.312E-04	CREBBP, SHH, PAX8, MITF, TP53
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.131E-05	6.312E-04	CYP2C9, CYP2D6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.525E-05	6.312E-04	CYP2C9, CYP2D6, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.406E-04	3.608E-03	PAX8, TP53
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	3.683E-04	4.604E-03	KMT2A, PAX8, TP53
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.406E-04	3.608E-03	CYP2C9, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05217	Basal cell carcinoma	8.693E-04	9.314E-03	SHH, TP53
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.212E-03	1.069E-02	CYP2C9, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.444E-03	1.069E-02	PAX8, TSHR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.567E-03	1.069E-02	PTPN1, CREBBP

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases