CMAUP Plant Collective Molecular Activities

Plant Name: Thalictrum glandulosissimum

Plant ID: NPO15847
Plant Latin Name: Thalictrum glandulosissimum
Taxonomy Genus: Thalictrum
Taxonomy Family: Ranunculaceae

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	LMNA;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2D6;

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.608E-07	3.501E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.038E-07	8.167E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	3.534E-06	1.924E-02	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.353E-05	5.894E-02	CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.283E-05	1.438E-01	CYP2D6, CYP3A4
CC	GO:0016020; membrane	GO:0031090; organelle membrane	1.732E-03	6.572E-01	CYP2D6, CYP3A4, GAA, LMNA
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	4.149E-02	1.000E+00	LMNA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.165E-04	1.109E-03	CYP2D6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.305E-04	1.109E-03	CYP2D6, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.230E-03	2.916E-02	CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1.392E-02	2.916E-02	GAA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	7.478E-03	2.916E-02	GAA
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.763E-02	2.916E-02	CYP3A4
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.837E-02	2.916E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	2.230E-02	2.916E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	2.058E-02	2.916E-02	LMNA
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.033E-02	2.916E-02	CYP3A4

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases