CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NMUR2;
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Hydrolase	GAA; ACHE;
Enzyme_unclassified	TDP1; HPGD; AKR1B1; GFER; ALDH1A1; POLB;
Protein Kinase	MAPK1;
Lyase	CA2; CA1; CA12; CA9; CA5B; CA5A; CA3; CA14; CA7; CA4; CA6;
Lysine demethylase	KDM4E;
Transferase	FUT7;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261

Showing 1 to 10 of 27 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.640E-06	6.140E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.795E-23	3.043E-19	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.056E-21	4.601E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	1.127E-05	1.067E-02	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	1.127E-05	1.067E-02	ADRA2A, ADRA2C
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	5.332E-06	6.140E-03	ADRA2A, CA2, CA4, CA9, HPGD
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.259E-08	1.317E-04	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.085E-30	1.107E-25	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	5.640E-06	6.140E-03	ADRA2A, ADRA2C
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.813E-05	2.268E-02	CA1, CA2

Showing 1 to 10 of 11 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.140E-29	3.454E-27	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	7.459E-04	2.735E-02	GAA, AKR1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.443E-03	3.969E-02	MAPK1, ADRA2C, ADRA2A
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6.012E-03	1.323E-01	NMUR2, ADRA2C, ADRA2A
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.302E-01	2.007E-01	MAPK1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4.363E-04	2.400E-02	CA2, CA4
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	9.787E-03	1.794E-01	ACHE, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.255E-01	2.007E-01	MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04916	Melanogenesis	1.267E-01	2.007E-01	MAPK1
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	1.219E-01	2.007E-01	CA2

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;

Showing 1 to 10 of 22 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cephalaria paphlagonica

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities