Plant Name: Derris reticulata
Taxonomic Information:
Plant ID: NPO15721
Plant Latin Name: Derris reticulata
Taxonomy Genus: Derris
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
647089
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GABBR1; | |
| BLM; | |
| GABRR1; | |
| CA12; CA9; | |
| KDM4A; KDM4C; | |
| KMT2A; | |
| SLC6A1; SLC6A11; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| GABA-A receptor | GABRR1 | GABA receptor rho-1 subunit | P24046 | CHEMBL3561 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Methyl-lysine/arginine binding protein | KDM4A | Lysine-specific demethylase 4A | O75164 | CHEMBL5896 |
| Methyl-lysine/arginine binding protein | KDM4C | Lysine-specific demethylase 4C | Q9H3R0 | CHEMBL6175 |
| Plant homeodomain | KMT2A | Histone-lysine N-methyltransferase MLL | Q03164 | CHEMBL1293299 |
| SLC superfamily of solute carriers | SLC6A1 | GABA transporter 1 | P30531 | CHEMBL1903 |
| SLC superfamily of solute carriers | SLC6A11 | GABA transporter 3 | P48066 | CHEMBL5208 |
| Small molecule receptor (family C GPCR) | GABBR1 | GABA-B receptor 1 | Q9UBS5 | CHEMBL2064 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:1900113; negative regulation of histone H3-K9 trimethylation | 2.946E-06 | 1.545E-02 | KDM4A, KDM4C |
| MF | GO:0005215; transporter activity | GO:0005332; gamma-aminobutyric acid:sodium symporter activity | 1.768E-06 | 1.545E-02 | SLC6A1, SLC6A11 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.103E-06 | 1.545E-02 | BLM, CA12, CA9, KDM4A, KDM4C, KMT2A |
| BP | GO:0051179; localization | GO:0006820; anion transport | 7.046E-06 | 2.402E-02 | CA12, CA9, GABRR1, SLC6A1, SLC6A11 |
| BP | GO:0051179; localization | GO:0015812; gamma-aminobutyric acid transport | 8.240E-06 | 2.402E-02 | SLC6A1, SLC6A11 |
| BP | GO:0008152; metabolic process | GO:0070544; histone H3-K36 demethylation | 1.323E-05 | 2.402E-02 | KDM4A, KDM4C |
| MF | GO:0003824; catalytic activity | GO:0051864; histone demethylase activity (H3-K36 specific) | 1.323E-05 | 2.402E-02 | KDM4A, KDM4C |
| MF | GO:0003824; catalytic activity | GO:0032454; histone demethylase activity (H3-K9 specific) | 2.673E-05 | 3.880E-02 | KDM4A, KDM4C |
| BP | GO:0008152; metabolic process | GO:0033169; histone H3-K9 demethylation | 3.083E-05 | 3.949E-02 | KDM4A, KDM4C |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09156 Nervous system | hsa04727 | GABAergic synapse | 1.128E-07 | 1.917E-06 | GABBR1, GABRR1, SLC6A11, SLC6A1 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 3.723E-05 | 3.165E-04 | CA12, CA9 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05032 | Morphine addiction | 1.097E-03 | 6.214E-03 | GABBR1, GABRR1 |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 9.680E-03 | 4.114E-02 | GABBR1, GABRR1 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05033 | Nicotine addiction | 2.179E-02 | 6.114E-02 | GABRR1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00310 | Lysine degradation | 2.824E-02 | 6.114E-02 | KMT2A |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03440 | Homologous recombination | 1.584E-02 | 5.385E-02 | BLM |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03460 | Fanconi anemia pathway | 2.877E-02 | 6.114E-02 | BLM |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 5.314E-02 | 6.579E-02 | GABBR1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04723 | Retrograde endocannabinoid signaling | 5.418E-02 | 6.579E-02 | GABRR1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9; |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
