Plant Name: Polytrichastrum alpinum
Taxonomic Information:
Plant ID: NPO15696
Plant Latin Name: Polytrichastrum alpinum
Taxonomy Genus: Polytrichastrum
Taxonomy Family: Polytrichaceae
Plant External Links:
NCBI TaxonomyDB:
129212
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 3.216E-08 | 7.004E-04 | PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:1903897; regulation of PERK-mediated unfolded protein response | 2.412E-07 | 2.626E-03 | PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response | 4.181E-07 | 3.035E-03 | PTPN1, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0046627; negative regulation of insulin receptor signaling pathway | 2.332E-06 | 8.805E-03 | PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:0060338; regulation of type I interferon-mediated signaling pathway | 5.548E-06 | 1.342E-02 | PTPN1, PTPN2 |
| MF | GO:0005488; binding | GO:0030971; receptor tyrosine kinase binding | 8.255E-06 | 1.634E-02 | PTPN1, PTPN2 |
| CC | GO:0044464; cell part | GO:0097443; sorting endosome | 6.212E-04 | 2.182E-01 | PTPN1 |
| MF | GO:0005488; binding | GO:0097677; STAT family protein binding | 6.212E-04 | 2.182E-01 | PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0004726; non-membrane spanning protein tyrosine phosphatase activity | 8.282E-04 | 2.540E-01 | PTPN2 |
| CC | GO:0044464; cell part | GO:0005783; endoplasmic reticulum | 2.386E-03 | 4.948E-01 | PTPN1, PTPN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 7.386E-03 | 1.574E-02 | PTPN1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 1.087E-02 | 1.574E-02 | PTPN1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 1.574E-02 | 1.574E-02 | PTPN2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 1.385E-02 | 1.574E-02 | PTPN1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
