Plant Name: Celastrus vulcanicola
Taxonomic Information:
Plant ID: NPO15653
Plant Latin Name: Celastrus vulcanicola
Taxonomy Genus: Celastrus
Taxonomy Family: Celastraceae
Plant External Links:
NCBI TaxonomyDB:
489983
Plant-of-the-World-Online:
51123-2
Used in Medicines:
Unknown.
Geographical Distribution:
Honduras; Mexico; El Salvador; Costa Rica; Guatemala; Belize; Nicaragua
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GLRA1; | |
| VDR; | |
| ABCB1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Glycine receptor | GLRA1 | Glycine receptor subunit alpha-1 | P23415 | CHEMBL5845 |
| Nuclear hormone receptor subfamily 1 group I | VDR | Vitamin D receptor | P11473 | CHEMBL1977 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0006811; ion transport | 3.084E-04 | 3.902E-01 | ABCB1, GLRA1, VDR |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 4.659E-04 | 3.902E-01 | VDR |
| MF | GO:0005488; binding | GO:0031406; carboxylic acid binding | 2.991E-04 | 3.902E-01 | GLRA1, VDR |
| CC | GO:0044456; synapse part | GO:0097060; synaptic membrane | 4.392E-02 | 1.000E+00 | GLRA1 |
| CC | GO:0032991; macromolecular complex | GO:0034702; ion channel complex | 4.452E-02 | 1.000E+00 | GLRA1 |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 4.918E-02 | 1.000E+00 | VDR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09155 Excretory system | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 7.034E-03 | 1.781E-02 | VDR |
| 09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 6.586E-03 | 1.781E-02 | ABCB1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04978 | Mineral absorption | 7.631E-03 | 1.781E-02 | VDR |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 1.857E-02 | ABCB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05152 | Tuberculosis | 2.646E-02 | 3.705E-02 | VDR |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 4.098E-02 | 4.389E-02 | GLRA1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 4.389E-02 | 4.389E-02 | ABCB1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| N00-N99: Diseases of the genitourinary system | Urinary incontinence | N39.3, N39.4, R32 | VDR; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | ABCB1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Rickets | E55 | VDR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | VDR; ABCB1; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | ABCB1; |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1; |
| NA: NA | Hypocalcemia | NA | VDR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypoparathyroidism | E20, E89.2, P71.4 | VDR; |
| N00-N99: Diseases of the genitourinary system | Chronic kidney disease | N18 | VDR; |
| C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ABCB1; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | VDR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | VDR; |
| NA: NA | Kidney transplantation | NA | VDR; |
| C00-D49: Neoplasms | Prostate cancer | C61 | VDR; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | ABCB1; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | VDR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperparathyroidism | E21.1 | VDR; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | VDR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Vitamin D deficiency | E55 | VDR; |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | VDR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | VDR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
