Plant Name: Glaucium oxylobum
Taxonomic Information:
Plant ID: NPO15612
Plant Latin Name: Glaucium oxylobum
Taxonomy Genus: Glaucium
Taxonomy Family: Papaveraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
673184-1
Used in Medicines:
Unknown.
Geographical Distribution:
Iran; Turkmenistan
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PTPN1; | |
| TDP1; HPGD; | |
| CREBBP; | |
| MAPT; HTT; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Bromodomain | CREBBP | CREB-binding protein | Q92793 | CHEMBL5747 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 5.788E-07 | 1.260E-02 | CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.892E-06 | 2.938E-02 | CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 1.271E-05 | 5.068E-02 | CYP2D6, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0042981; regulation of apoptotic process | 1.539E-05 | 5.068E-02 | CREBBP, HPGD, HTT, LMNA, MAPT, PTPN1 |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 1.059E-05 | 5.068E-02 | HTT, MAPT |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 4.858E-05 | 1.175E-01 | CYP2D6, CYP3A4 |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 7.249E-05 | 1.435E-01 | MAPT, PTPN1 |
| BP | GO:0009987; cellular process | GO:2001234; negative regulation of apoptotic signaling pathway | 1.028E-04 | 1.799E-01 | HTT, LMNA, PTPN1 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 1.074E-04 | 1.799E-01 | CYP2D6, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0010821; regulation of mitochondrion organization | 1.260E-04 | 1.960E-01 | HTT, LMNA, MAPT |
| BP | GO:0065007; biological regulation | GO:0031648; protein destabilization | 1.646E-04 | 2.389E-01 | CREBBP, HTT |
| CC | GO:0044464; cell part | GO:0097443; sorting endosome | 2.793E-03 | 5.382E-01 | PTPN1 |
| CC | GO:0043226; organelle | GO:0016604; nuclear body | 3.575E-03 | 5.873E-01 | CREBBP, LMNA, MAPT |
| CC | GO:0016020; membrane | GO:0016020; membrane | 3.979E-03 | 6.077E-01 | CYP2D6, CYP3A4, HPGD, HTT, LMNA, MAPT, PTPN1, TDP1 |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 4.099E-03 | 6.077E-01 | CREBBP, CYP2D6, CYP3A4, HTT, LMNA, MAPT, PTPN1, TDP1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 4.157E-04 | 7.012E-03 | CYP2D6, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 4.653E-04 | 7.012E-03 | CYP2D6, CYP3A4 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 4.781E-04 | 7.012E-03 | PTPN1, CREBBP |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 3.190E-03 | 3.509E-02 | CREBBP, HTT |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 6.128E-02 | 9.361E-02 | LMNA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 5.829E-02 | 9.361E-02 | CREBBP |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 6.383E-02 | 9.361E-02 | CREBBP |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04110 | Cell cycle | 5.445E-02 | 9.361E-02 | CREBBP |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04310 | Wnt signaling pathway | 6.213E-02 | 9.361E-02 | CREBBP |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 6.085E-02 | 9.361E-02 | PTPN1 |
Human Diseases Associated with the Target Proteins of the Plant
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
