CMAUP Plant Collective Molecular Activities

Plant Name: Cnidium monnieri

Taxonomic Information:

Plant ID: NPO15544
Plant Latin Name: Cnidium monnieri
Taxonomy Genus: Cnidium
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 94007
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea; China

Traditional Medicine System:

TCM

Medicinal Functions:

Antipruritic; Antirheumatic; Aphrodisiac; Astringent; Carminative; Sedative; Vermifuge; Vulnerary

Geographical Distribution:

South Korea; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA14; CA9; CA12;
Cysteine protease	CASP7; CASP1;
Enzyme_unclassified	USP2; BRCA1;
Transcription Factor	TP53;
Plant homeodomain	KMT2A;
Unclassified	RAB9A; HTT; HBB; FABP4; NPC1; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP2A13; CYP1A2; CYP2A6; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	HBB	Hemoglobin beta chain	P68871	CHEMBL4331
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.394E-11	3.036E-07	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6
MF	GO:0005488; binding	GO:0019825; oxygen binding	8.241E-10	5.982E-06	CYP1A1, CYP1A2, CYP1B1, CYP2A13, HBB
MF	GO:0005488; binding	GO:0020037; heme binding	2.703E-09	8.408E-06	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HBB
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	7.306E-09	1.768E-05	CYP1A1, CYP1A2, CYP1B1, CYP2A13
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.035E-08	2.049E-05	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HBB
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	3.314E-08	5.154E-05	CYP1A1, CYP2A13, CYP2A6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.105E-07	1.176E-04	CA12, CA14, CA9, HBB
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.134E-07	1.176E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.285E-07	3.538E-04	CA12, CA14, CA9
BP	GO:0050896; response to stimulus	GO:0010038; response to metal ion	6.173E-07	4.801E-04	CYP1A1, CYP1A2, FABP4, KMT2A, NPC1, TP53
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	1.019E-06	7.393E-04	CYP2A13, CYP2A6
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.659E-06	1.165E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	4.351E-06	2.707E-03	CYP1A1, CYP1A2, CYP1B1, CYP2A6, NPC1
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.565E-06	3.275E-03	CYP1A1, CYP2A13, CYP2A6
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.104E-06	3.497E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.373E-09	5.142E-07	CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.512E-08	5.142E-07	CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	8.252E-06	1.290E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.763E-07	1.306E-05	CA12, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.548E-05	2.887E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.590E-05	3.488E-04	CYP2A6, CYP1A2, CYP1A1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.507E-04	2.981E-03	CASP7, LMNA, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.131E-03	7.998E-03	CYP1A1, CYP1B1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.367E-03	8.449E-03	CASP7, CASP1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	1.176E-03	7.998E-03	CASP1, TP53
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	9.483E-06	1.290E-04	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53; CA9;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Beta thalassemia	D56.1	HBB;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CASP1;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	CASP1;
C00-D49: Neoplasms	Cancer	C00-C96	TP53; CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases