Plant Name: Glochidion zeylanicum
Taxonomic Information:
Plant ID: NPO15526
Plant Latin Name: Glochidion zeylanicum
Taxonomy Genus: Glochidion
Taxonomy Family: Phyllanthaceae
Plant External Links:
NCBI TaxonomyDB:
271535
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| MAPK1; | |
| TP53; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0071417; cellular response to organonitrogen compound | 3.343E-05 | 1.851E-01 | MAPK1, TP53, TSHR |
| BP | GO:0008152; metabolic process | GO:0051972; regulation of telomerase activity | 3.770E-05 | 1.851E-01 | MAPK1, TP53 |
| BP | GO:0008283; cell proliferation | GO:0042127; regulation of cell proliferation | 5.154E-05 | 1.870E-01 | LMNA, MAPK1, TP53, TSHR |
| BP | GO:0009987; cellular process | GO:0007154; cell communication | 3.532E-04 | 2.312E-01 | MAPK1, TP53, TSHR |
| BP | GO:0051179; localization | GO:0060341; regulation of cellular localization | 3.703E-04 | 2.312E-01 | LMNA, MAPK1, TP53 |
| BP | GO:0040011; locomotion | GO:0040012; regulation of locomotion | 3.804E-04 | 2.312E-01 | LMNA, MAPK1, TP53 |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 4.141E-04 | 2.312E-01 | TSHR |
| MF | GO:0005488; binding | GO:0019902; phosphatase binding | 4.251E-04 | 2.314E-01 | MAPK1, TP53 |
| MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 1.449E-03 | 3.669E-01 | TP53 |
| MF | Unclassified; | GO:0004707; MAP kinase activity | 2.896E-03 | 4.752E-01 | MAPK1 |
| MF | Unclassified; | GO:0004708; MAP kinase kinase activity | 3.103E-03 | 4.861E-01 | MAPK1 |
| MF | GO:0003824; catalytic activity | GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity | 3.309E-03 | 4.881E-01 | MAPK1 |
| CC | Unclassified; | GO:0031143; pseudopodium | 3.516E-03 | 4.883E-01 | MAPK1 |
| CC | GO:0044464; cell part | GO:0032839; dendrite cytoplasm | 5.167E-03 | 5.598E-01 | MAPK1 |
| CC | GO:0043226; organelle | GO:0016604; nuclear body | 7.790E-03 | 6.213E-01 | LMNA, TP53 |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 1.347E-02 | 8.342E-01 | LMNA, MAPK1, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.336E-06 | 1.416E-04 | LMNA, MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 1.216E-05 | 6.444E-04 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 4.604E-05 | 7.562E-04 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 2.454E-05 | 7.562E-04 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05213 | Endometrial cancer | 3.965E-05 | 7.562E-04 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 6.214E-05 | 7.562E-04 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 5.651E-05 | 7.562E-04 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 6.408E-05 | 7.562E-04 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 7.421E-05 | 7.562E-04 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 6.605E-05 | 7.562E-04 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 7.847E-05 | 7.562E-04 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.168E-04 | 1.032E-03 | MAPK1, TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 2.055E-04 | 1.502E-03 | MAPK1, TP53 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 2.125E-04 | 1.502E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 3.145E-04 | 1.961E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 2.611E-04 | 1.730E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 2.125E-04 | 1.502E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 6.069E-04 | 3.280E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 5.833E-04 | 3.280E-03 | MAPK1, TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 6.189E-04 | 3.280E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 9.553E-04 | 4.822E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 1.700E-03 | 7.835E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 1.293E-03 | 6.230E-03 | MAPK1, TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
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>> Targets derived from weak experimental activities
