CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Protein Kinase	MAPK1;
Transcription Factor	TP53;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 4 of 4 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	3.343E-05	1.851E-01	MAPK1, TP53, TSHR
BP	GO:0008152; metabolic process	GO:0051972; regulation of telomerase activity	3.770E-05	1.851E-01	MAPK1, TP53
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	5.154E-05	1.870E-01	LMNA, MAPK1, TP53, TSHR
BP	GO:0009987; cellular process	GO:0007154; cell communication	3.532E-04	2.312E-01	MAPK1, TP53, TSHR
BP	GO:0051179; localization	GO:0060341; regulation of cellular localization	3.703E-04	2.312E-01	LMNA, MAPK1, TP53
BP	GO:0040011; locomotion	GO:0040012; regulation of locomotion	3.804E-04	2.312E-01	LMNA, MAPK1, TP53
CC	Unclassified;	GO:0031143; pseudopodium	3.516E-03	4.883E-01	MAPK1
CC	GO:0044464; cell part	GO:0032839; dendrite cytoplasm	5.167E-03	5.598E-01	MAPK1
CC	GO:0043226; organelle	GO:0016604; nuclear body	7.790E-03	6.213E-01	LMNA, TP53
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	1.347E-02	8.342E-01	LMNA, MAPK1, TP53

Showing 1 to 10 of 16 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	2.125E-04	1.502E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	5.833E-04	3.280E-03	MAPK1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	9.553E-04	4.822E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.700E-03	7.835E-03	MAPK1, TP53
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.336E-06	1.416E-04	LMNA, MAPK1, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.055E-04	1.502E-03	MAPK1, TP53
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	2.125E-04	1.502E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.216E-05	6.444E-04	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	4.604E-05	7.562E-04	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.454E-05	7.562E-04	MAPK1, TP53

Showing 1 to 10 of 23 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;

Showing 1 to 10 of 14 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Glochidion zeylanicum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities