Plant Name: Euonymus japonicus
Taxonomic Information:
Plant ID: NPO1552
Plant Latin Name: Euonymus japonicus
Taxonomy Genus: Euonymus
Taxonomy Family: Celastraceae
Plant External Links:
NCBI TaxonomyDB:
212708
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Unknown.
Geographical Distribution:
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Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PRKCA; | |
| CA2; CA7; CA4; CA12; | |
| NR1H4; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Kinase | PRKCA | Protein kinase C alpha | P17252 | CHEMBL299 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 3.528E-12 | 7.682E-08 | CA12, CA2, CA4, CA7 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.520E-10 | 1.655E-06 | CA12, CA2, CA4, CA7 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.500E-10 | 2.540E-06 | CA12, CA2, CA4, CA7 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 5.462E-09 | 1.982E-05 | CA12, CA2, CA4, CA7, NR1H4, PRKCA |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 2.412E-07 | 4.775E-04 | CA2, CA7 |
| BP | GO:0051179; localization | GO:2001225; regulation of chloride transport | 3.614E-06 | 6.054E-03 | CA2, CA7 |
| BP | GO:0023052; signaling | GO:0032230; positive regulation of synaptic transmission, GABAergic | 6.262E-06 | 9.740E-03 | CA2, CA7 |
| BP | GO:0065007; biological regulation | GO:0050801; ion homeostasis | 2.036E-05 | 2.770E-02 | CA12, CA2, CA7, NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0035403; histone kinase activity (H3-T6 specific) | 6.212E-04 | 2.182E-01 | PRKCA |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 1.349E-03 | 3.316E-01 | CA2, CA4 |
| CC | GO:0044464; cell part | GO:0005791; rough endoplasmic reticulum | 1.482E-02 | 1.000E+00 | CA4 |
| CC | GO:0044464; cell part | GO:0048471; perinuclear region of cytoplasm | 1.536E-02 | 1.000E+00 | CA4, PRKCA |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 5.351E-12 | 3.371E-10 | CA12, CA2, CA4, CA7 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 1.892E-05 | 5.961E-04 | CA2, CA4 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04971 | Gastric acid secretion | 2.006E-04 | 3.160E-03 | CA2, PRKCA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.847E-04 | 3.160E-03 | CA2, NR1H4 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04972 | Pancreatic secretion | 3.378E-04 | 4.256E-03 | CA2, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04916 | Melanogenesis | 2.963E-02 | 4.966E-02 | PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04070 | Phosphatidylinositol signaling system | 2.905E-02 | 4.966E-02 | PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05146 | Amoebiasis | 2.963E-02 | 4.966E-02 | PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 3.285E-02 | 4.966E-02 | PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04723 | Retrograde endocannabinoid signaling | 2.992E-02 | 4.966E-02 | PRKCA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2; |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; |
| NA: NA | Edema | NA | CA2; |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
