CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C; CNR1; ADRA2A; CNR2;
Peptide receptor (family A GPCR)	NMUR2;
Hydrolase	GAA; ACHE;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 2 group B	RXRA;
Oxidoreductase	ALOX5;
Metallo protease	MMP2;
Enzyme_unclassified	POLB;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 2 group B	RXRA	Retinoid X receptor alpha	P19793	CHEMBL2061
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	2.121E-06	5.774E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	2.121E-06	5.774E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	2.121E-06	5.774E-03	CNR1, CNR2
BP	GO:0032501; multicellular organismal process	GO:0019233; sensory perception of pain	4.217E-06	7.063E-03	CNR1, CNR2, MAPK1
BP	GO:0032501; multicellular organismal process	GO:0006940; regulation of smooth muscle contraction	7.830E-06	1.066E-02	ADRA2A, ADRA2C, NMUR2
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	1.061E-06	5.774E-03	CNR1, CNR2
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.061E-06	5.774E-03	ADRA2A, ADRA2C
MF	GO:0005488; binding	GO:0051379; epinephrine binding	9.886E-06	1.196E-02	ADRA2A, ADRA2C
MF	Unclassified;	GO:0004871; signal transducer activity	2.280E-05	2.027E-02	ADRA2A, ADRA2C, CNR1, CNR2, MAPK1, NMUR2, RXRA
MF	GO:0005488; binding	GO:0031690; adrenergic receptor binding	5.383E-05	3.781E-02	ADRA2A, ADRA2C

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.596E-07	3.704E-05	CNR2, CNR1, NMUR2, ADRA2C, ADRA2A
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.190E-04	4.559E-03	MAPK1, ADRA2C, ADRA2A
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	1.312E-03	1.612E-02	MMP2, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.550E-03	1.612E-02	MMP2, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.612E-03	1.612E-02	CNR1, MAPK1
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.328E-04	4.559E-03	RXRA, MAPK1
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	4.992E-04	1.028E-02	RXRA, MAPK1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.671E-04	6.878E-03	MMP2, MAPK1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.495E-03	1.612E-02	RXRA, MMP2, MAPK1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.612E-03	1.612E-02	MMP2, MAPK1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; MMP2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP2;
C00-D49: Neoplasms	Cutaneous T-cell lymphoma	C84.0, C84.1	RXRA;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Pedicularis rex

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities