CMAUP Plant Collective Molecular Activities

Plant Name: Luffa aegyptiaca

Taxonomic Information:

Plant ID: NPO1551
Plant Latin Name: Luffa aegyptiaca
Taxonomy Genus: Luffa
Taxonomy Family: Cucurbitaceae

Plant External Links:

NCBI TaxonomyDB: 3670
Plant-of-the-World-Online: 293060-1

Used in Medicines:

Country/Region:

Brazil; Madagascar; Angola; South Africa; Indonesia; India; Congo; Zimbabwe; Jordan; Swaziland; Thailand; South Korea

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Ayurveda; Siddha

Geographical Distribution:

Brazil; Madagascar; Bangladesh; Liberia; Sudan; Guinea; Cambodia; Malawi; Ethiopia; Rwanda; Somalia; Swaziland; Vanuatu; Nigeria; Bolivia; Cameroon; Cote d'Ivoire; Benin; Ghana; Cuba; Thailand; Venezuela; Senegal; Burkina Faso; Zimbabwe; China; Jordan; Dominican Republic; Sierra Leone; Eritrea; Netherlands; Uganda; Gambia; Tanzania; Indonesia; New Caledonia; Mauritius; Trinidad and Tobago; Mauritania; Gabon; South Korea; Guinea-Bissau; Mali; Yemen; Haiti; Jamaica; Albania; Angola; Chad; Mexico; South Africa; India; Djibouti; Congo; Mozambique; Colombia; Burundi; Kenya; Niger; Fiji; Zambia

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ATP1A1;
Enzyme_unclassified	RECQL;
Lyase	CA2; CA1; CA12; CA9; CA7; CA3; CA14; CA5B; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Transcription Factor	TP53; STAT3;
SLC superfamily of solute carriers	SLCO4C1; SLCO1B1;
Unclassified	ITGAL; RAB9A; LMNA; NPC1; MAPT; PAX8;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Hydrolase	ATP1A1	Sodium/potassium-transporting ATPase alpha-1 chain	P05023	CHEMBL1807
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
SLC superfamily of solute carriers	SLCO4C1	Solute carrier organic anion transporter family member 4C1	Q6ZQN7	CHEMBL2073690
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	STAT3	Signal transducer and activator of transcription 3	P40763	CHEMBL4026
Unclassified	ITGAL	Leukocyte adhesion glycoprotein LFA-1 alpha	P20701	CHEMBL1803
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	3.853E-12	9.322E-09	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2, RORC, TP53
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.118E-07	1.522E-04	ATP1A1, CA2, CA4, CA9, SLCO1B1, SLCO4C1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.739E-30	3.787E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0005496; steroid binding	4.313E-06	5.218E-03	ATP1A1, ESR2, NPC1, RORC
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.821E-06	5.407E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.585E-24	1.044E-19	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.104E-22	2.234E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.405E-05	2.094E-02	CA1, CA2
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	2.640E-05	2.211E-02	ATP1A1, CA2, CA9, NPC1, RORC, STAT3, TP53
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	3.392E-05	2.547E-02	ESR2, RORC, STAT3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	4.876E-05	2.766E-03	STAT3, RAB9A, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	1.578E-04	3.156E-03	STAT3, ITGAL, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.108E-04	2.953E-03	PAX8, TP53
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6.914E-05	2.766E-03	CA2, ATP1A1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	5.787E-04	7.269E-03	STAT3, TP53
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	7.269E-04	7.269E-03	CA2, ATP1A1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.138E-03	9.753E-03	PAX8, STAT3, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	6.694E-04	7.269E-03	PAX8, ATP1A1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.694E-04	7.269E-03	CA2, ATP1A1
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	1.219E-03	9.753E-03	CA2, ATP1A1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	ATP1A1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ATP1A1;
NA: NA	Congestive cardiac insufficiency	NA	ATP1A1;
C00-D49: Neoplasms	Allergic conjunctivitis	C91.0, H10, H10.45, T78.4	ITGAL;
C00-D49: Neoplasms	Multiple myeloma	C90	STAT3;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
H00-H59: Diseases of the eye and adnexa	Dry eye disease	H16.229	ITGAL;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	ATP1A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ITGAL;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ATP1A1;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
NA: NA	Arrhythmias	NA	ATP1A1;
C00-D49: Neoplasms	Cancer	C00-C96	STAT3; ATP1A1; TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Renal transplantation	D89.8	ITGAL;
C00-D49: Neoplasms	Solid tumours	C00-D48	STAT3; TP53;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	STAT3;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ATP1A1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ATP1A1;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	ITGAL;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Hyperhidrosis	R61	ATP1A1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ITGAL; STAT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases