CMAUP Plant Collective Molecular Activities

Plant Name: Muscari botryoides

Taxonomic Information:

Plant ID: NPO15502
Plant Latin Name: Muscari botryoides
Taxonomy Genus: Muscari
Taxonomy Family: Hyacinthaceae

Plant External Links:

NCBI TaxonomyDB: 81769
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Italy

Traditional Medicine System:

Geographical Distribution:

Italy

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPL; HSD17B10;
Hydrolase	GAA;
Lyase	CA2; CA7; CA4; CA6; CA12; CA9; CA1; CA14;
Transcription Factor	NFKB1; TP53;
Unclassified	MAPT; PFKFB3; RAB9A;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16875	CHEMBL2331053
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.895E-08	4.126E-05	CYP2C19, CYP2C9, CYP2D6
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.638E-07	1.288E-03	CA1, CA12, CA2, CA4, CA6, CA7, CA9, TP53
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.054E-06	4.750E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.565E-06	7.128E-03	CYP2C19, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.682E-21	3.664E-17	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.560E-17	4.965E-13	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.199E-15	1.742E-11	CA1, CA12, CA2, CA4, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.310E-05	1.426E-02	CYP2C19, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.524E-05	1.580E-02	CA1, CA2
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	4.561E-05	3.310E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.807E-21	4.518E-19	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.296E-05	2.019E-03	CYP2C9, CYP2D6, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.818E-04	5.578E-03	CYP2C9, CYP2D6, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	3.221E-04	5.946E-03	RAB9A, TP53, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.019E-03	1.368E-02	CYP2C9, GAA, ALPL, CYP2C19, HSD17B10, XDH
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.374E-04	5.578E-03	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.795E-04	5.946E-03	CYP2C9, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.989E-03	1.870E-02	MAPT, TP53, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.733E-03	1.870E-02	CYP2C9, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.961E-03	1.870E-02	TP53, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	PFKFB3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
NA: NA	Edema	NA	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases