CMAUP Plant Collective Molecular Activities

Plant Name: Angelica sinensis

Taxonomic Information:

Plant ID: NPO15462
Plant Latin Name: Angelica sinensis
Taxonomy Genus: Angelica
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 165353
Plant-of-the-World-Online: 77065778-1

Used in Medicines:

Country/Region:

United States; China

Traditional Medicine System:

TCM

Medicinal Functions:

Alterative; Analgesic; Anticholesterolemic; Antiinflammatory; Antispasmodic; Deobstruent; Emollient; Hepatic; Laxative; Sedative; Vasodilator; Women's complaints

Geographical Distribution:

United States; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; ADORA3; ADORA2A; ADORA1; FFAR4; HCAR2;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	BLM; ADK; HSD17B10; ALOX15;
GABA-A receptor	GABRR1;
Lyase	CA2; CA12; CA9; CA14; CA5B; CA7; CA5A; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	TP53; NFKB1;
Plant homeodomain	KMT2A;
Unclassified	LMNA; FABP3; GLI1; FABP5; FABP4; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2A6; CYP2A13;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	GLI1	Zinc finger protein GLI1	P08151	CHEMBL5461
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.718E-14	1.871E-10	CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.086E-13	2.215E-09	CA12, CA2, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.849E-10	5.752E-07	BLM, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, KMT2A, MMP1, MMP2, MMP9, PPARA, TP53
MF	GO:0005488; binding	GO:0005504; fatty acid binding	2.163E-07	3.436E-04	FABP3, FABP4, FABP5, FFAR4
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	2.445E-07	3.436E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	5.852E-07	6.707E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	1.982E-06	2.055E-03	ADORA2A, CA2, CA7
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	2.941E-06	2.561E-03	ADORA1, ADORA2A, FFAR4, NFKB1, PPARA
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	3.769E-06	2.902E-03	CYP2A13, CYP2A6
CC	GO:0044464; cell part	GO:0030673; axolemma	3.865E-06	2.902E-03	ADORA1, ADORA2A, MAPT
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	9.116E-06	5.839E-03	CYP1A2, CYP2A13, CYP2A6
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.129E-05	6.645E-03	CA2, CA7
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	1.129E-05	6.645E-03	ADORA1, ADORA2A
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.568E-05	8.344E-03	FABP3, FABP4, FABP5
BP	GO:0050896; response to stimulus	GO:0009628; response to abiotic stimulus	1.746E-05	8.964E-03	ADORA1, BLM, CA2, KMT2A, LMNA, MAPT, MMP2, NFKB1, PPARA, TP53
MF	GO:0003824; catalytic activity	GO:0016712; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1.770E-05	8.964E-03	CYP1A2, CYP2A13, CYP2A6
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.494E-19	1.414E-14	CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.853E-18	2.205E-16	CA12, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	8.443E-08	5.024E-06	HCAR2, ADORA2A, ADORA1, PPARA, GLI1, NFKB1, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.938E-07	7.687E-06	FABP3, FABP4, FABP5, MMP1, PPARA
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.067E-06	3.173E-05	MMP1, MMP2, MMP9, TP53
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	9.499E-05	1.615E-03	MMP1, MMP2, GLI1, TP53, MMP9, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	7.770E-05	1.541E-03	ADORA3, ADORA1, TP53, NFKB1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.697E-04	2.244E-03	GABRR1, ADORA2A, ADORA3, ADORA1, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.636E-04	2.244E-03	FABP4, ADORA1, TSHR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.591E-04	3.990E-03	CYP2A6, CYP2A13, CYP1A2
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	3.688E-04	3.990E-03	KMT2A, TP53, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.053E-04	5.011E-03	CYP2A6, CYP2A13, CYP1A2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.503E-05	8.336E-04	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9; TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1; MAPT;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADORA2A; ADK;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA1; ADORA2A;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1; HCAR2;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; ADORA3; MMP9; TP53; MMP2; CA9;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HCAR2;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA1; ADORA2A; ADORA3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; HCAR2; FFAR1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; TP53; MMP2; CA9;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1; FFAR1;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A; HCAR2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases