CMAUP Plant Collective Molecular Activities

Plant Name: Vitex rotundifolia

Taxonomic Information:

Plant ID: NPO15454
Plant Latin Name: Vitex rotundifolia
Taxonomy Genus: Vitex
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 413484
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Australia; China

Traditional Medicine System:

TCM

Geographical Distribution:

Australia; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Enzyme_unclassified	RECQL; NOX4; ALOX15;
Protein Kinase	FLT3;
Lyase	CA2; CA1; CA12; CA9; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP12;
Transcription Factor	HIF1A;
ATP-binding cassette	ABCG2;
Unclassified	LMNA; FABP3; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.205E-14	3.489E-10	CA1, CA12, CA14, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.974E-12	8.595E-09	CA1, CA12, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.204E-07	1.638E-04	CA1, CA12, CA2, CA4, CA7, CA9, MMP12, NR1H4, RORC
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	3.646E-06	2.695E-03	ALOX15, CYP1B1, FABP4, FFAR4, FLT3, HIF1A, NOX4, NR1H4, RORC
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.712E-06	2.695E-03	CA2, CA7
MF	GO:0005488; binding	GO:0005504; fatty acid binding	3.685E-06	2.695E-03	FABP3, FABP4, FFAR4
BP	GO:0065007; biological regulation	GO:0055081; anion homeostasis	1.329E-05	8.039E-03	CA12, FABP3, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.489E-18	1.195E-13	CA1, CA12, CA14, CA2, CA4, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.299E-17	4.935E-16	CA12, CA1, CA2, CA4, CA7, CA9, CA14
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.290E-05	1.195E-03	CA2, NR1H4, ABCG2
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.882E-04	3.650E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Cancer	C00-C96	FLT3; HIF1A; CA1; CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	FLT3; HIF1A; CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	AML	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Pancreatic cancer	C25	FLT3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	FLT3;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
C00-D49: Neoplasms	CLL	NA	FLT3;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	FLT3;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
C00-D49: Neoplasms	Breast cancer	C50	FLT3; CA9;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases