Plant Name: Stemona parviflora
Taxonomic Information:
Plant ID: NPO15438
Plant Latin Name: Stemona parviflora
Taxonomy Genus: Stemona
Taxonomy Family: Stemonaceae
Plant External Links:
NCBI TaxonomyDB:
339780
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Metallo protease | MMP3 | Matrix metalloproteinase 3 | P08254 | CHEMBL283 |
| Unclassified | IL1B | Interleukin-1 beta | P01584 | CHEMBL1909490 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:1901698; response to nitrogen compound | 7.708E-05 | 2.398E-01 | CASP1, IL1B, MMP3 |
| BP | GO:0032501; multicellular organismal process | GO:0050715; positive regulation of cytokine secretion | 9.959E-05 | 2.711E-01 | CASP1, IL1B |
| MF | GO:0003824; catalytic activity | GO:0004175; endopeptidase activity | 1.781E-03 | 4.577E-01 | CASP1, MMP3 |
| MF | GO:0003824; catalytic activity | GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis | 2.018E-03 | 4.577E-01 | CASP1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 2.224E-05 | 3.195E-04 | IL1B, CASP1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 2.390E-05 | 3.195E-04 | IL1B, CASP1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 3.018E-05 | 3.195E-04 | IL1B, CASP1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 4.153E-05 | 3.195E-04 | IL1B, CASP1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 8.961E-05 | 4.096E-04 | IL1B, MMP3 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05323 | Rheumatoid arthritis | 5.990E-05 | 3.195E-04 | IL1B, MMP3 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05132 | Salmonella infection | 5.467E-05 | 3.195E-04 | IL1B, CASP1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 2.271E-04 | 9.083E-04 | IL1B, CASP1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05143 | African trypanosomiasis | 5.241E-03 | 1.677E-02 | IL1B |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05020 | Prion diseases | 5.241E-03 | 1.677E-02 | IL1B |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | MMP3; |
| I00-I99: Diseases of the circulatory system | Ischemic stroke | I61-I63 | MMP3; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1; MMP3; |
| H00-H59: Diseases of the eye and adnexa | Corneal ulcers | H16.0 | MMP3; |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | MMP3; |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
