CMAUP Plant Collective Molecular Activities

Plant Name: Brucea mollis

Taxonomic Information:

Plant ID: NPO15436
Plant Latin Name: Brucea mollis
Taxonomy Genus: Brucea
Taxonomy Family: Simaroubaceae

Plant External Links:

NCBI TaxonomyDB: 43723
Plant-of-the-World-Online: 60469132-2

Used in Medicines:

Unknown.

Geographical Distribution:

Bangladesh; Myanmar; Philippines; India; Cambodia; Vietnam; China; Laos; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transient receptor potential channel	TRPA1;
Protein Kinase	PLK1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Protein Kinase	PLK1	Serine/threonine-protein kinase PLK1	P53350	CHEMBL3024
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007077; mitotic nuclear envelope disassembly	1.519E-05	1.315E-01	LMNA, PLK1
BP	GO:0051179; localization	GO:1900180; regulation of protein localization to nucleus	3.880E-04	8.453E-01	LMNA, PLK1
BP	GO:0032501; multicellular organismal process	GO:0050968; detection of chemical stimulus involved in sensory perception of pain	4.659E-04	8.453E-01	TRPA1
BP	GO:0032501; multicellular organismal process	GO:0050955; thermoception	4.659E-04	8.453E-01	TRPA1
CC	GO:0044464; cell part	GO:0032421; stereocilium bundle	7.764E-04	9.392E-01	TRPA1
MF	GO:0005215; transporter activity	GO:0015278; calcium-release channel activity	2.793E-03	1.000E+00	TRPA1
MF	GO:0005215; transporter activity	GO:0015276; ligand-gated ion channel activity	2.143E-02	1.000E+00	TRPA1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.106E-02	2.085E-02	LMNA
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1.463E-02	2.085E-02	TRPA1
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	1.240E-02	2.085E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.344E-02	2.085E-02	LMNA
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.463E-02	2.085E-02	PLK1
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	1.834E-02	2.085E-02	PLK1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.085E-02	2.085E-02	LMNA
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	1.982E-02	2.085E-02	PLK1
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	1.849E-02	2.085E-02	PLK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases