CMAUP Plant Collective Molecular Activities

Plant Name: Angelica decursiva

Taxonomic Information:

Plant ID: NPO15394
Plant Latin Name: Angelica decursiva
Taxonomy Genus: Angelica
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 52491
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Analgesic; Antiarthritic; Antiseptic; Antispasmodic; Carminative; Expectorant; Lenitive; Stimulant; Stomachic; Tonic

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Enzyme_unclassified	ADK; USP2; BRCA1;
Lyase	CA14; CA12; CA9;
Cysteine protease	CASP1; CASP7;
Transcription Factor	TP53;
Plant homeodomain	KMT2A;
Unclassified	LMNA; HTT; HBB; FABP4; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A13; CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	HBB	Hemoglobin beta chain	P68871	CHEMBL4331
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	3.865E-08	8.416E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	9.264E-08	9.887E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.362E-07	9.887E-04	CA12, CA14, CA9, HBB
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	5.102E-07	2.222E-03	ADORA2A, BRCA1, CA9, CASP1, CASP7, CYP1A2, NPC1, TP53
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.997E-07	2.222E-03	CA12, CA14, CA9
BP	GO:0009987; cellular process	GO:0006915; apoptotic process	2.995E-06	5.545E-03	ADORA2A, BRCA1, CASP1, CASP7, HTT, KMT2A, TP53
BP	GO:0048511; rhythmic process	GO:0042752; regulation of circadian rhythm	3.489E-06	5.545E-03	ADORA1, ADORA2A, TP53, USP2
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	3.375E-06	5.545E-03	ADORA1, ADORA2A

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.720E-07	5.175E-05	CA12, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	2.589E-04	9.968E-03	ADORA3, ADORA1, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADORA2A; ADK;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK; CASP1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3; TP53; CA9;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA1; ADORA2A; ADORA3;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Beta thalassemia	D56.1	HBB;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53; CA9;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CASP1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases