CMAUP Plant Collective Molecular Activities

Plant Name: Alnus japonica

Taxonomic Information:

Plant ID: NPO15361
Plant Latin Name: Alnus japonica
Taxonomy Genus: Alnus
Taxonomy Family: Betulaceae

Plant External Links:

NCBI TaxonomyDB: 109063
Plant-of-the-World-Online: 294936-1

Used in Medicines:

Country/Region:

South Korea

Traditional Medicine System:

Medicinal Functions:

Cancer

Geographical Distribution:

South Africa; Russia; China; Japan; South Korea; Taiwan

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	PTGS1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	2.071E-04	2.505E-01	PTGS1
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	3.106E-04	2.941E-01	NR1H4
MF	GO:0060089; molecular transducer activity	GO:0004887; thyroid hormone receptor activity	7.247E-04	4.641E-01	NR1H4
MF	GO:0005488; binding	GO:0046965; retinoid X receptor binding	1.553E-03	6.501E-01	NR1H4
MF	GO:0005488; binding	GO:0016922; ligand-dependent nuclear receptor binding	2.173E-03	7.511E-01	NR1H4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5.592E-03	1.418E-02	PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	6.191E-03	1.418E-02	PTGS1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	7.088E-03	1.418E-02	NR1H4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.117E-02	1.460E-02	PTGS1
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	1.216E-02	1.460E-02	PTGS1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.201E-01	1.201E-01	PTGS1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases