Plant Name: Jacobaea adonidifolia
Taxonomic Information:
Plant ID: NPO15164
Plant Latin Name: Jacobaea adonidifolia
Taxonomy Genus: Jacobaea
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
189226
Plant-of-the-World-Online:
n.a.
Geographical Distribution
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See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPR35; | |
| TDP1; RECQL; HPGD; AKR1B1; APEX1; POLB; | |
| ACHE; | |
| TEK; INSR; MET; EGFR; NUAK1; KDR; SRC; IGF1R; CSNK2A1; | |
| CA12; | |
| NR1H4; | |
| SLC22A6; | |
| SMAD3; HSPA1A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Kinase | TEK | Tyrosine-protein kinase TIE-2 | Q02763 | CHEMBL4128 |
Showing 1 to 10 of 22 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 1.749E-09 | 3.462E-06 | EGFR, IGF1R, INSR, KDR, SRC |
| BP | GO:0009987; cellular process | GO:0043066; negative regulation of apoptotic process | 1.116E-08 | 1.429E-05 | AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, NR1H4, SMAD3, SRC, TEK |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 6.677E-07 | 2.019E-04 | EGFR, INSR, MET, SRC, TEK |
| BP | GO:0009987; cellular process | GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway | 8.968E-07 | 2.508E-04 | EGFR, IGF1R, INSR, KDR, MET, SRC, TEK |
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 1.238E-06 | 3.329E-04 | APEX1, POLB |
| BP | GO:0050896; response to stimulus | GO:1901653; cellular response to peptide | 3.130E-06 | 7.100E-04 | AKR1B1, APEX1, IGF1R, INSR, SRC |
| BP | GO:0065007; biological regulation | GO:0048878; chemical homeostasis | 5.602E-06 | 1.081E-03 | AKR1B1, CA12, EGFR, GPR35, INSR, MET, NR1H4, SMAD3 |
| BP | GO:0050896; response to stimulus | GO:0034614; cellular response to reactive oxygen species | 6.256E-06 | 1.174E-03 | AKR1B1, APEX1, EGFR, SRC |
| BP | GO:0009987; cellular process | GO:0071363; cellular response to growth factor stimulus | 6.957E-06 | 1.295E-03 | EGFR, INSR, KDR, SMAD3, SRC |
| BP | GO:0050896; response to stimulus | GO:0014070; response to organic cyclic compound | 1.081E-05 | 1.913E-03 | APEX1, CSNK2A1, EGFR, HPGD, SLC22A6, SRC, TEK |
Showing 1 to 10 of 27 entries
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 5.974E-04 | 4.224E-03 | POLB, APEX1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 1.963E-09 | 9.719E-08 | SRC, INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 1.283E-07 | 3.175E-06 | INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 1.393E-06 | 2.758E-05 | INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 4.518E-06 | 5.592E-05 | INSR, TEK, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 1.246E-05 | 1.370E-04 | SMAD3, INSR, EGFR, IGF1R |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.158E-12 | 1.146E-10 | SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04144 | Endocytosis | 8.138E-09 | 2.685E-07 | SMAD3, SRC, KDR, MET, EGFR, HSPA1A, IGF1R |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04510 | Focal adhesion | 2.290E-06 | 3.319E-05 | SRC, KDR, MET, EGFR, IGF1R |
| 09150 Organismal Systems | 09149 Aging | hsa04213 | Longevity regulating pathway - multiple species | 4.608E-05 | 4.562E-04 | INSR, HSPA1A, IGF1R |
Showing 1 to 10 of 18 entries
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | KDR; EGFR; |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | SRC; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | IGF1R; SRC; |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | EGFR; |
| C00-D49: Neoplasms | Melanoma | C43 | KDR; EGFR; |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | IGF1R; KDR; EGFR; |
Showing 1 to 10 of 114 entries
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
