Plant Name: Magnolia denudata
Taxonomic Information:
Plant ID: NPO15064
Plant Latin Name: Magnolia denudata
Taxonomy Genus: Magnolia
Taxonomy Family: Magnoliaceae
Plant External Links:
NCBI TaxonomyDB:
85856
Plant-of-the-World-Online:
554678-1
Used in Medicines:
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Anodyne; Antifungal; Astringent; Carminative; Cytotoxic; Diaphoretic; Hypotensive; Sedative; Tonic; Uterine tonic
Geographical Distribution:
China
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Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| PTAFR; | |
| MAPK1; | |
| ALOX15; ALDH1A1; | |
| MMP3; | |
| MAPT; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Metallo protease | MMP3 | Matrix metalloproteinase 3 | P08254 | CHEMBL283 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Small molecule receptor (family A GPCR) | PTAFR | Platelet activating factor receptor | P25105 | CHEMBL250 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0071241; cellular response to inorganic substance | 3.760E-05 | 1.365E-01 | ALOX15, MAPK1, MMP3 |
| BP | GO:0050896; response to stimulus | GO:0031663; lipopolysaccharide-mediated signaling pathway | 6.938E-05 | 1.992E-01 | MAPK1, PTAFR |
| BP | GO:0009987; cellular process | GO:0031334; positive regulation of protein complex assembly | 8.365E-05 | 1.992E-01 | ALOX15, MAPT, MMP3 |
| BP | GO:0050896; response to stimulus | GO:0071242; cellular response to ammonium ion | 9.924E-05 | 1.992E-01 | MAPK1, PTAFR |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 3.274E-04 | 2.415E-01 | MAPK1, MAPT |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 8.282E-04 | 2.677E-01 | TSHR |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 8.282E-04 | 2.677E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0050473; arachidonate 15-lipoxygenase activity | 1.242E-03 | 3.109E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 1.242E-03 | 3.109E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 1.242E-03 | 3.109E-01 | ALOX15 |
| MF | GO:0005488; binding | GO:0005497; androgen binding | 1.656E-03 | 3.605E-01 | ALDH1A1 |
| CC | GO:0044464; cell part | GO:0030424; axon | 4.683E-03 | 5.176E-01 | MAPK1, MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 8.214E-04 | 4.299E-02 | MMP3, MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 8.513E-04 | 4.299E-02 | ALOX15, MAPK1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.325E-03 | 4.461E-02 | LMNA, MAPK1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 1.900E-03 | 4.797E-02 | MAPK1, MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 2.652E-03 | 5.356E-02 | MAPK1, TSHR |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 5.065E-03 | 6.550E-02 | PTAFR, TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 1.154E-02 | 6.550E-02 | MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 2.571E-02 | 6.550E-02 | MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 2.883E-02 | 6.550E-02 | MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 2.883E-02 | 6.550E-02 | MAPK1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PTAFR; |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTAFR; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Cardiac arrhythmias | I47-I49 | PTAFR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | PTAFR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
| A00-B99: Certain infectious and parasitic diseases | Septic shock | A41.9 | PTAFR; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | MMP3; |
| H00-H59: Diseases of the eye and adnexa | Conjunctivitis | H10 | PTAFR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | PTAFR; MAPK1; |
| H00-H59: Diseases of the eye and adnexa | Corneal ulcers | H16.0 | MMP3; |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | PTAFR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Thrombocytopenia | D69.6, P61.0 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | MMP3; |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3; |
| G00-G99: Diseases of the nervous system G00-G99 | Brain ischaemia | G45.9, I67.8 | PTAFR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MAPK1; |
| H00-H59: Diseases of the eye and adnexa | Ocular allergy | H00-H59 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Cerebral infarction | I63 | PTAFR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PTAFR; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | MMP3; |
| I00-I99: Diseases of the circulatory system | Ischemic stroke | I61-I63 | MMP3; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
