Plant Name: Dioscorea collettii var. hypoglauca
Taxonomic Information:
Plant ID: NPO15018.1
Plant Latin Name: Dioscorea collettii var. hypoglauca
Taxonomy Genus: Dioscorea
Taxonomy Family: Dioscoreaceae
Plant External Links:
NCBI TaxonomyDB:
357959
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| HKDC1; ALOX15; USP2; | |
| KDM4E; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | HKDC1 | Putative hexokinase HKDC1 | Q2TB90 | CHEMBL1741200 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 9.002E-07 | 9.801E-03 | CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.250E-06 | 1.225E-02 | CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0009820; alkaloid metabolic process | 3.149E-06 | 1.371E-02 | CYP1A2, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 9.886E-06 | 2.691E-02 | CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 9.886E-06 | 2.691E-02 | CYP1A2, CYP3A4 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 3.030E-05 | 7.330E-02 | ALOX15, CYP1A2, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 3.781E-05 | 8.233E-02 | CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0006706; steroid catabolic process | 4.854E-05 | 8.808E-02 | CYP1A2, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0032451; demethylase activity | 1.104E-04 | 1.849E-01 | CYP1A2, KDM4E |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.473E-04 | 2.138E-01 | CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 2.125E-04 | 2.892E-01 | ALOX15, CYP1A2 |
| CC | GO:0044464; cell part | GO:0031234; extrinsic component of cytoplasmic side of plasma membrane | 2.944E-02 | 1.000E+00 | ALOX15 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.527E-07 | 4.582E-06 | CYP1A2, ALOX15, CYP3A4 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 2.289E-04 | 2.176E-03 | CYP1A2, CYP3A4 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.876E-04 | 2.176E-03 | CYP1A2, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 3.241E-04 | 2.176E-03 | CYP1A2, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 3.627E-04 | 2.176E-03 | CYP1A2, CYP3A4 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 8.386E-04 | 3.594E-03 | HKDC1, CYP1A2, ALOX15, CYP3A4 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 4.576E-04 | 2.288E-03 | CYP1A2, CYP3A4 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.273E-02 | 3.472E-02 | HKDC1 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 1.999E-03 | 6.662E-03 | CYP1A2 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00524 | Butirosin and neomycin biosynthesis | 1.999E-03 | 6.662E-03 | HKDC1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
