CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	HKDC1; ALOX15; USP2;
Lysine demethylase	KDM4E;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HKDC1	Putative hexokinase HKDC1	Q2TB90	CHEMBL1741200
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963

Showing 1 to 8 of 8 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.250E-06	1.225E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	3.149E-06	1.371E-02	CYP1A2, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	9.886E-06	2.691E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	9.886E-06	2.691E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	4.854E-05	8.808E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	2.125E-04	2.892E-01	ALOX15, CYP1A2
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	2.944E-02	1.000E+00	ALOX15
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	9.002E-07	9.801E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.030E-05	7.330E-02	ALOX15, CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.781E-05	8.233E-02	CYP1A2, CYP3A4

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.527E-07	4.582E-06	CYP1A2, ALOX15, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.289E-04	2.176E-03	CYP1A2, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.876E-04	2.176E-03	CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.241E-04	2.176E-03	CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.627E-04	2.176E-03	CYP1A2, CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.273E-02	3.472E-02	HKDC1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.999E-03	6.662E-03	CYP1A2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00524	Butirosin and neomycin biosynthesis	1.999E-03	6.662E-03	HKDC1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.576E-04	2.288E-03	CYP1A2, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	8.386E-04	3.594E-03	HKDC1, CYP1A2, ALOX15, CYP3A4

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Dioscorea collettii var. hypoglauca

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities