Plant Name: Lathyrus tingitanus
Taxonomic Information:
Plant ID: NPO14947
Plant Latin Name: Lathyrus tingitanus
Taxonomy Genus: Lathyrus
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
3862
Plant-of-the-World-Online:
502046-1
Used in Medicines:
Unknown.
Geographical Distribution:
Australia; Italy; Portugal; Algeria; Mexico; Tunisia; Costa Rica; Morocco; New Zealand; Spain
Geographical Distribution
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See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ADORA3; ADORA2A; ADORA1; GPR35; | |
| RECQL; TDP1; ADK; HPGD; AKR1B1; APEX1; POLB; | |
| ACHE; | |
| TEK; INSR; MET; EGFR; SRC; KDR; IGF1R; NUAK1; CSNK2A1; | |
| CA2; CA1; CA12; CA9; CA7; CA14; | |
| KDM4E; | |
| PTGS2; | |
| STAT1; | |
| FUT7; | |
| KMT2A; | |
| SLC22A6; | |
| SMAD3; LMNA; RAB9A; NPC1; THPO; HSPA1A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | ADK | Adenosine kinase | P55263 | CHEMBL3589 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Showing 1 to 10 of 42 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 4.834E-10 | 6.192E-07 | CA1, CA12, CA14, CA2, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.363E-08 | 7.809E-06 | CA1, CA12, CA2, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 5.448E-08 | 2.524E-05 | EGFR, IGF1R, INSR, KDR, SRC |
| BP | GO:0008283; cell proliferation | GO:0048661; positive regulation of smooth muscle cell proliferation | 6.265E-07 | 1.819E-04 | AKR1B1, EGFR, HPGD, PTGS2, STAT1 |
| BP | GO:0009987; cellular process | GO:0001973; adenosine receptor signaling pathway | 7.957E-07 | 2.113E-04 | ADORA1, ADORA2A, ADORA3 |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 8.930E-07 | 2.288E-04 | EGFR, INSR, MET, SRC, TEK, THPO |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 1.135E-06 | 2.746E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 1.299E-06 | 3.041E-04 | ADORA1, CYP1A1, LMNA, PTGS2, SMAD3, SRC, TEK |
| BP | GO:0008152; metabolic process | GO:0045429; positive regulation of nitric oxide biosynthetic process | 1.844E-06 | 4.016E-04 | EGFR, INSR, PTGS2, SMAD3 |
| BP | GO:0008283; cell proliferation | GO:0008285; negative regulation of cell proliferation | 1.984E-06 | 4.235E-04 | ADORA1, ADORA2A, ADORA3, CYP1B1, HSPA1A, KMT2A, LMNA, PTGS2, SMAD3, STAT1 |
Showing 1 to 10 of 50 entries
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 7.186E-13 | 9.845E-11 | CA12, CA1, CA2, CA7, CA9, CA14 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 8.060E-05 | 9.202E-04 | CYP1A2, CYP1A1, CYP1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 2.452E-04 | 1.976E-03 | CYP1A2, CYP1A1, CYP1B1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 4.835E-04 | 2.880E-03 | CYP1A2, CYP1A1, CYP1B1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 1.166E-08 | 5.323E-07 | ADORA2A, SRC, INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 7.460E-06 | 1.703E-04 | INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 7.348E-05 | 9.152E-04 | INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 6.388E-05 | 8.807E-04 | INSR, TEK, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 1.720E-04 | 1.683E-03 | SMAD3, INSR, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 2.847E-04 | 2.167E-03 | SRC, KDR, PTGS2 |
Showing 1 to 10 of 25 entries
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A; |
| A00-B99: Certain infectious and parasitic diseases | Sepsis | A40, A41 | ADORA1; |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR; |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3; |
| C00-D49: Neoplasms | Breast cancer | C50 | IGF1R; KDR; INSR; EGFR; CA9; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR; |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET; |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR; EGFR; |
Showing 1 to 10 of 160 entries
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
