CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Protein Kinase	FLT3;
Lyase	CA4; CA12; CA7;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	ALOX15; NOX4; TNKS2; TNKS;
Metallo protease	MMP12;
Transcription Factor	NFKB1; HIF1A; TP53;
Unclassified	FABP3; LMNA; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239

Showing 1 to 10 of 19 entries

Previous1 2Next

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0009967; positive regulation of signal transduction	2.853E-08	1.553E-04	ALOX15, CYP1B1, FFAR4, FLT3, HIF1A, MMP12, NFKB1, NOX4, TNKS, TNKS2, TP53
BP	GO:0008152; metabolic process	GO:1902893; regulation of pri-miRNA transcription from RNA polymerase II promoter	4.321E-06	4.039E-03	HIF1A, PPARA, TP53
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	5.494E-06	4.389E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.644E-06	4.389E-03	CA12, CA4, CA7
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	9.985E-06	6.394E-03	ALOX15, CYP1B1, FFAR4, FLT3, HIF1A, NFKB1, NOX4, TP53
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.042E-05	6.481E-03	CA12, CA4, CA7
BP	GO:0050896; response to stimulus	GO:1901652; response to peptide	1.766E-05	9.807E-03	FABP3, FFAR4, NFKB1, PPARA, TP53
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	1.953E-05	9.807E-03	ALOX15, HIF1A, NOX4, TNKS, TNKS2, TP53
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	1.978E-05	9.807E-03	CYP1B1, HIF1A, NOX4, TP53
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	1.996E-05	9.807E-03	CA12, CA7, FABP3, FFAR1, HIF1A, NOX4, TP53

Showing 1 to 10 of 14 entries

Previous1 2Next

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.901E-07	4.411E-05	CA12, CA4, CA7
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.996E-04	5.394E-03	LMNA, TP53, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.660E-05	1.098E-03	FABP3, FABP5, PPARA
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.351E-05	1.098E-03	FLT3, TP53, HIF1A
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	4.679E-04	7.019E-03	FLT3, HIF1A, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	2.577E-04	5.394E-03	PPARA, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.247E-04	8.032E-03	FLT3, TP53, NFKB1

Showing 1 to 7 of 7 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	FLT3; TP53;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Solid tumours	C00-D48	FLT3; HIF1A; TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	AML	NA	FLT3;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Breast cancer	C50	FLT3;

Showing 1 to 10 of 41 entries

Previous1 2 3 4 5Next

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Ceratophyllum submersum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities