CMAUP Plant Collective Molecular Activities

Plant Name: Bupleurum scorzonerifolium

Taxonomic Information:

Plant ID: NPO1484
Plant Latin Name: Bupleurum scorzonerifolium
Taxonomy Genus: Bupleurum
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 48105
Plant-of-the-World-Online: 839388-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Japan; China; Russia; Mongolia; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR4; FFAR1;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	BLM; CDA; ALOX15;
GABA-A receptor	GABRR1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Transcription Factor	TP53; NFKB1;
Plant homeodomain	KMT2A;
Unclassified	FABP3; LMNA; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005504; fatty acid binding	5.446E-09	1.186E-04	FABP3, FABP4, FABP5, FFAR4
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.061E-06	3.298E-03	FABP3, FABP4, FABP5

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.288E-07	2.220E-05	FABP3, FABP4, FABP5, PPARA
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.759E-04	5.686E-03	LMNA, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.511E-04	5.686E-03	PPARA, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.939E-04	7.984E-03	PPARA, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	3.683E-04	7.145E-03	KMT2A, TP53, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.406E-04	5.834E-03	ALOX15, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6.084E-04	8.431E-03	CDA, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	CDA; TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; TP53;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases