CMAUP Plant Collective Molecular Activities

Plant Name: Amomum longiligulare

Taxonomic Information:

Plant ID: NPO1479
Plant Latin Name: Amomum longiligulare
Taxonomy Genus: Amomum
Taxonomy Family: Zingiberaceae

Plant External Links:

NCBI TaxonomyDB: 648859
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Vietnam; China

Traditional Medicine System:

TCM

Geographical Distribution:

Vietnam; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	ALPI; P4HB; AKR1B1; POLB;
Hydrolase	GAA;
Protein Kinase	MAPK1;
Lyase	CA2; CA1; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Toll-like and Il-1 receptors	TLR2;
Unclassified	HTT; RAB9A; LMNA; NPC1; FABP3; FABP5; FABP2; FABP4; MAPT;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	ALPI	Intestinal alkaline phosphatase	P09923	CHEMBL5573
Enzyme_unclassified	P4HB	Protein disulfide-isomerase	P07237	CHEMBL5422
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.305E-11	1.421E-07	CA1, CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.604E-09	6.986E-06	CA1, CA12, CA2, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.585E-09	1.456E-05	CA1, CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	4.374E-08	7.327E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.251E-07	2.950E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.224E-06	7.842E-04	AKR1B1, CYP1A1, CYP1A2, CYP1B1, NPC1, PPARD
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	1.613E-06	9.493E-04	CYP1A1, LMNA, P4HB, PPARA, PPARD, TLR2
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	3.019E-06	1.610E-03	AKR1B1, CA2, CYP1A2, FABP3, NPC1, PPARA, TLR2, TSHR
BP	GO:0008152; metabolic process	GO:0006631; fatty acid metabolic process	3.491E-06	1.804E-03	CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.565E-06	1.804E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	4.677E-06	2.108E-03	AKR1B1, CA12, CA2, CA7, FABP3, FABP4, HTT, MAPK1, NPC1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.738E-06	2.108E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.738E-06	2.108E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.074E-06	2.449E-03	CA2, CA7
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	6.817E-06	2.650E-03	AKR1B1, CYP1A1, CYP1B1, FABP3, MAPK1, NPC1, POLB, TLR2
BP	GO:0007610; behavior	GO:0007610; behavior	9.121E-06	3.103E-03	GAA, HTT, MAPK1, MAPT, NPC1, PPARA, TLR2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.214E-05	4.004E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.396E-05	4.471E-03	ALPI, CA1, CA12, CA2, CA4, CA7, PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0009636; response to toxic substance	2.000E-05	6.050E-03	AKR1B1, CYP1A1, CYP1B1, MAPK1, POLB, TLR2
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	2.863E-05	8.203E-03	AKR1B1, CYP1A1, CYP1A2, CYP1B1, GAA, P4HB, PPARD, XDH
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.029E-05	8.470E-03	CA1, CA2
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.716E-05	1.011E-02	CYP1A1, CYP1A2, CYP1B1
CC	GO:0044464; cell part	GO:0005773; vacuole	1.172E-04	2.438E-02	AKR1B1, GAA, HTT, NPC1, RAB9A
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.228E-04	2.499E-02	AKR1B1, MAPK1, MAPT
CC	GO:0044421; extracellular region part	GO:0070062; extracellular exosome	2.739E-04	4.849E-02	AKR1B1, CA1, CA2, CA4, FABP3, FABP4, FABP5, GAA, MAPK1, NPC1, P4HB, RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.256E-11	3.113E-09	CA12, CA1, CA2, CA4, CA7
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	4.791E-10	3.306E-08	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.345E-05	8.091E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.201E-05	1.988E-03	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.431E-04	3.292E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.021E-04	3.984E-03	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.885E-05	8.091E-04	CYP1A2, XDH
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.646E-03	3.053E-02	MAPK1, PPARA, TSHR
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4.696E-04	8.100E-03	CA2, CA4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	8.025E-04	1.230E-02	GAA, AKR1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases