Plant Name: Delphinium fangshanense
Taxonomic Information:
Plant ID: NPO14566
Plant Latin Name: Delphinium fangshanense
Taxonomy Genus: Delphinium
Taxonomy Family: Ranunculaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ALPL; HSD17B10; | |
| GAA; | |
| CA2; CA5B; CA6; CA12; CA1; CA5A; | |
| NFKB1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.043E-14 | 1.483E-10 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 9.914E-07 | 2.159E-03 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 3.614E-06 | 7.155E-03 | CA1, CA2 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.456E-17 | 3.170E-13 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 5.644E-15 | 6.145E-11 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 2.921E-17 | 1.898E-15 | CA12, CA1, CA5B, CA2, CA5A, CA6 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 1.144E-02 | 8.721E-02 | CA2 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00280 | Valine, leucine and isoleucine degradation | 2.375E-02 | 8.721E-02 | HSD17B10 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00790 | Folate biosynthesis | 6.980E-03 | 8.721E-02 | ALPL |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.490E-02 | 8.721E-02 | GAA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 2.717E-02 | 8.721E-02 | NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 2.814E-02 | 8.721E-02 | NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 3.591E-02 | 8.721E-02 | NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 5.033E-02 | 8.721E-02 | NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 5.081E-02 | 8.721E-02 | NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
