CMAUP Plant Collective Molecular Activities

Plant Name: Walsura yunnanensis

Taxonomic Information:

Plant ID: NPO14561
Plant Latin Name: Walsura yunnanensis
Taxonomy Genus: Walsura
Taxonomy Family: Meliaceae

Plant External Links:

NCBI TaxonomyDB: 1679371
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.078E-14	3.685E-10	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	2.084E-12	9.076E-09	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0005506; iron ion binding	8.120E-12	1.965E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.128E-10	2.233E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.066E-10	2.233E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.571E-10	6.617E-07	CYP19A1, CYP1A1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.320E-10	1.015E-06	CYP1A2, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.024E-08	9.695E-06	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	8.226E-08	6.889E-05	CYP1A1, CYP1A2, CYP1B1
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	2.982E-07	2.239E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	9.002E-07	5.601E-04	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	9.002E-07	5.601E-04	CYP1A2, CYP2C9
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	4.198E-06	2.285E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	9.886E-06	4.784E-03	CYP1A2, CYP2C9
BP	GO:0009987; cellular process	GO:0071280; cellular response to copper ion	1.168E-05	5.345E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0009056; catabolic process	1.736E-05	7.132E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	2.035E-05	8.057E-03	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.297E-16	1.371E-11	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.153E-15	3.433E-11	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
CC	GO:0016020; membrane	GO:0031090; organelle membrane	1.667E-04	5.501E-02	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, LMNA
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	7.106E-04	1.864E-01	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, LMNA, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.678E-11	1.079E-09	CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.418E-09	4.197E-08	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.131E-08	7.161E-08	CYP2C9, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.122E-07	1.566E-06	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	8.161E-07	2.584E-06	CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.527E-07	7.255E-07	CYP2C9, CYP1A2, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.814E-06	4.923E-06	CYP2C9, CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.174E-06	5.163E-06	CYP2C9, CYP1A2, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.329E-05	9.140E-05	CYP2C9, CYP1A2, CYP1A1, CYP2C19, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.616E-04	4.970E-04	CYP2C9, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	8.513E-04	1.470E-03	CYP2C9, CYP2C19
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.999E-03	3.164E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases