CMAUP Plant Collective Molecular Activities

Plant Name: Aquilaria sinensis

Taxonomic Information:

Plant ID: NPO14558
Plant Latin Name: Aquilaria sinensis
Taxonomy Genus: Aquilaria
Taxonomy Family: Thymelaeaceae

Plant External Links:

NCBI TaxonomyDB: 210372
Plant-of-the-World-Online: 830849-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1; PTPN11; PTPN6;
Enzyme_unclassified	FAAH; TDP1; TERT; HSD11B1; HSD17B10; CES2;
Lyase	CA2; CA12; CA1; CA9; CA7; CA14; CA5B;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Serine protease	PLG;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	NFKB1;
Unclassified	LMNA; FABP3; FABP5; FABP2; FABP4; MAPT; THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	CES2	Carboxylesterase 2	O00748	CHEMBL3180
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN11	Protein-tyrosine phosphatase 2C	Q06124	CHEMBL3864
Protein Phosphatase	PTPN6	Protein-tyrosine phosphatase 1C	P29350	CHEMBL3166
Serine protease	PLG	Plasminogen	P00747	CHEMBL1801
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.867E-13	5.299E-09	CA1, CA12, CA14, CA2, CA5B, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.924E-11	7.633E-08	CA1, CA12, CA2, CA5B, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.685E-08	4.176E-05	CA1, CA12, CA2, CA5B, CA7, CA9, ESR1, PPARA, PPARD, PPARG, PTPN1
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	6.705E-08	8.588E-05	FABP2, FABP3, FABP4, FABP5
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.093E-06	7.002E-04	ESR1, PPARA, PPARD, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	2.322E-06	1.297E-03	ESR1, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0033277; abortive mitotic cell cycle	2.493E-06	1.357E-03	PTPN11, PTPN6
BP	GO:0051179; localization	GO:0015908; fatty acid transport	3.876E-06	2.004E-03	FABP3, PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0001223; transcription coactivator binding	4.189E-06	2.073E-03	ESR1, PPARA, TERT
BP	GO:0008152; metabolic process	GO:0006631; fatty acid metabolic process	6.565E-06	2.917E-03	CES2, FAAH, FABP3, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.471E-06	3.190E-03	CA2, CA7
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	1.121E-05	4.521E-03	FABP3, LMNA, PLG, PPARD, PPARG, PTPN6, TERT, TLR2
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	1.422E-05	5.340E-03	CA2, CA9, LMNA, MAPT, NFKB1, PPARD, PPARG, PTPN1, PTPN11, TDP1, TERT
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	2.485E-05	8.233E-03	PPARA, PPARG
BP	GO:0051179; localization	GO:0032368; regulation of lipid transport	2.495E-05	8.233E-03	NFKB1, PPARA, PPARG, PTPN11
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.436E-17	1.837E-12	CA1, CA12, CA14, CA2, CA5B, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.995E-16	1.975E-14	CA12, CA1, CA5B, CA2, CA7, CA9, CA14
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.048E-11	5.186E-10	FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.345E-05	7.738E-04	PTPN1, PTPN11, PPARA, NFKB1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	2.615E-04	4.315E-03	PTPN6, PTPN11, ESR1, TLR2
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	1.720E-04	3.858E-03	PTPN11, PPARA, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.949E-04	3.858E-03	PTPN6, NFKB1, TLR2
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	1.849E-03	2.614E-02	THPO, PTPN6, PTPN11
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2.306E-03	2.854E-02	CYP3A4, CES2
09160 Human Diseases	09167 Infectious diseases	hsa05168	Herpes simplex infection	2.893E-03	2.900E-02	PTPN11, NFKB1, TLR2
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.519E-03	2.900E-02	NFKB1, PPARD

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Prostate cancer	C61	ESR1;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1;
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1;
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1;
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1;
C00-D49: Neoplasms	Breast cancer	C50	ESR1;
NA: NA	Gonorrheal vaginitis	NA	ESR1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1;
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1;
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1;
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1;
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1;
NA: NA	Menopausal disorder	NA	ESR1;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1;
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1;
NA: NA	Postmenopausal disorder	NA	ESR1;
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1;
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1;
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1;
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1;
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1;
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1;
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases