CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	KDR; AURKB; AURKA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.410E-06	1.283E-02	CYP1A1, CYP1B1
BP	GO:0008152; metabolic process	GO:0035404; histone-serine phosphorylation	3.534E-06	1.283E-02	AURKA, AURKB
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.014E-05	2.207E-02	AURKA, AURKB, KDR
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.124E-05	2.224E-02	CYP1A1, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.353E-05	2.267E-02	CYP1A1, CYP1B1
BP	GO:0008152; metabolic process	GO:1903409; reactive oxygen species biosynthetic process	1.476E-05	2.296E-02	CYP1A1, CYP1B1
BP	GO:0009987; cellular process	GO:0090068; positive regulation of cell cycle process	2.764E-05	3.344E-02	AURKA, AURKB, CYP1A1
BP	GO:0009987; cellular process	GO:0051716; cellular response to stimulus	4.718E-05	5.136E-02	AURKA, AURKB, CYP1A1, CYP1B1, KDR
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	5.359E-07	8.751E-03	AURKA, AURKB
CC	GO:0043226; organelle	GO:0000780; condensed nuclear chromosome, centromeric region	3.534E-06	1.283E-02	AURKA, AURKB

Showing 1 to 10 of 17 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.885E-05	4.658E-04	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.219E-05	4.658E-04	CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.305E-04	5.545E-04	CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.615E-02	3.921E-02	CYP1A1
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	1.516E-02	3.921E-02	KDR
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	3.038E-02	6.455E-02	AURKA
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	4.950E-02	7.835E-02	KDR
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	6.096E-05	4.658E-04	CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.647E-04	5.601E-04	CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.974E-02	7.835E-02	KDR

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	AML	NA	KDR;

Showing 1 to 10 of 38 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Eupatorium semiserratum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities