Plant Name: Eupatorium semiserratum
Taxonomic Information:
Plant ID: NPO14553
Plant Latin Name: Eupatorium semiserratum
Taxonomy Genus: Eupatorium
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
103755
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | AURKA | Serine/threonine-protein kinase Aurora-A | O14965 | CHEMBL4722 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| CC | GO:0032991; macromolecular complex | GO:0032133; chromosome passenger complex | 5.359E-07 | 8.751E-03 | AURKA, AURKB |
| MF | GO:0003824; catalytic activity | GO:0035174; histone serine kinase activity | 8.038E-07 | 8.751E-03 | AURKA, AURKB |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 2.410E-06 | 1.283E-02 | CYP1A1, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0035404; histone-serine phosphorylation | 3.534E-06 | 1.283E-02 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0000780; condensed nuclear chromosome, centromeric region | 3.534E-06 | 1.283E-02 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0031616; spindle pole centrosome | 3.534E-06 | 1.283E-02 | AURKA, AURKB |
| BP | GO:0008152; metabolic process | GO:0046777; protein autophosphorylation | 1.014E-05 | 2.207E-02 | AURKA, AURKB, KDR |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.124E-05 | 2.224E-02 | CYP1A1, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 1.353E-05 | 2.267E-02 | CYP1A1, CYP1B1 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 1.353E-05 | 2.267E-02 | CYP1A1, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:1903409; reactive oxygen species biosynthetic process | 1.476E-05 | 2.296E-02 | CYP1A1, CYP1B1 |
| CC | GO:0043226; organelle | GO:0051233; spindle midzone | 2.485E-05 | 3.183E-02 | AURKA, AURKB |
| BP | GO:0009987; cellular process | GO:0090068; positive regulation of cell cycle process | 2.764E-05 | 3.344E-02 | AURKA, AURKB, CYP1A1 |
| BP | GO:0009987; cellular process | GO:0051716; cellular response to stimulus | 4.718E-05 | 5.136E-02 | AURKA, AURKB, CYP1A1, CYP1B1, KDR |
| MF | GO:0003824; catalytic activity | GO:0004712; protein serine/threonine/tyrosine kinase activity | 4.596E-05 | 5.136E-02 | AURKA, AURKB |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 5.283E-05 | 5.478E-02 | CYP1A1, CYP1B1 |
| CC | GO:0043226; organelle | GO:0005876; spindle microtubule | 7.348E-05 | 6.646E-02 | AURKA, AURKB |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 3.885E-05 | 4.658E-04 | CYP1A1, CYP1B1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 6.096E-05 | 4.658E-04 | CYP1A1, CYP1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 8.219E-05 | 4.658E-04 | CYP1A1, CYP1B1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.305E-04 | 5.545E-04 | CYP1A1, CYP1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.647E-04 | 5.601E-04 | CYP1A1, CYP1B1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 1.516E-02 | 3.921E-02 | KDR |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.615E-02 | 3.921E-02 | CYP1A1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04114 | Oocyte meiosis | 3.038E-02 | 6.455E-02 | AURKA |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 4.974E-02 | 7.835E-02 | KDR |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04510 | Focal adhesion | 4.950E-02 | 7.835E-02 | KDR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR; |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR; |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR; |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR; |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR; |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR; |
| C00-D49: Neoplasms | Melanoma | C43 | KDR; |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR; |
| C00-D49: Neoplasms | Renal cancer | C64 | KDR; |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | KDR; |
| C00-D49: Neoplasms | AML | NA | KDR; |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | KDR; |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | KDR; |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | AURKA; AURKB; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | KDR; |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | AURKA; |
| C00-D49: Neoplasms | Glioma | C71 | KDR; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | KDR; |
| C00-D49: Neoplasms | Breast cancer | C50 | KDR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | AURKA; KDR; |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | KDR; |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR; |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR; |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | KDR; |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | KDR; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | AURKB; |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR; |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR; |
| C00-D49: Neoplasms | Haematological malignancies | C81-C86 | AURKA; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | AURKA; |
| C00-D49: Neoplasms | Liver cancer | C22 | KDR; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | KDR; |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | AURKA; AURKB; KDR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
