Plant Name: Pyrus pyraster
Taxonomic Information:
Plant ID: NPO14500
Plant Latin Name: Pyrus pyraster
Taxonomy Genus: Pyrus
Taxonomy Family: Rosaceae
Plant External Links:
NCBI TaxonomyDB:
356590
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
AlbaniaTraditional Medicine System:
Geographical Distribution:
Albania
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HRH3; HRH4; HRH1; HRH2; | |
| NPSR1; TSHR; | |
| BLM; GLA; | |
| GABRR2; | |
| KDM4E; | |
| NFKB1; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | GLA | Alpha-galactosidase A | P06280 | CHEMBL2524 |
| GABA-A receptor | GABRR2 | GABA receptor rho-2 subunit | P28476 | CHEMBL2375 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Small molecule receptor (family A GPCR) | HRH3 | Histamine H3 receptor | Q9Y5N1 | CHEMBL264 |
| Small molecule receptor (family A GPCR) | HRH4 | Histamine H4 receptor | Q9H3N8 | CHEMBL3759 |
| Small molecule receptor (family A GPCR) | HRH1 | Histamine H1 receptor | P35367 | CHEMBL231 |
| Small molecule receptor (family A GPCR) | HRH2 | Histamine H2 receptor | P25021 | CHEMBL1941 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0060089; molecular transducer activity | GO:0004969; histamine receptor activity | 2.587E-12 | 5.634E-08 | HRH1, HRH2, HRH3, HRH4 |
| BP | GO:0065007; biological regulation | GO:0045761; regulation of adenylate cyclase activity | 4.224E-06 | 1.840E-02 | HRH3, HRH4, TSHR |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 7.305E-06 | 2.434E-02 | CYP2C19, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0007186; G-protein coupled receptor signaling pathway | 1.332E-05 | 2.637E-02 | GABRR2, HRH1, HRH2, HRH3, HRH4, NPSR1, TSHR |
| BP | GO:0008152; metabolic process | GO:0032769; negative regulation of monooxygenase activity | 2.673E-05 | 4.158E-02 | GLA, NFKB1 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 3.206E-05 | 4.654E-02 | CYP2C19, CYP3A4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 1.830E-08 | 1.537E-06 | GABRR2, HRH1, HRH3, HRH2, HRH4, TSHR |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.828E-04 | 7.676E-03 | CYP3A4, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.039E-03 | 2.910E-02 | CYP3A4, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.464E-03 | 3.073E-02 | CYP3A4, CYP2C19 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 4.190E-03 | 7.039E-02 | LMNA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04020 | Calcium signaling pathway | 6.827E-03 | 9.558E-02 | HRH1, HRH2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 8.286E-03 | 9.943E-02 | NFKB1, TSHR |
| 09100 Metabolism | 09107 Glycan biosynthesis and metabolism | hsa00603 | Glycosphingolipid biosynthesis - globo series | 9.759E-03 | 1.025E-01 | GLA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 4.992E-02 | 1.038E-01 | NFKB1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 4.992E-02 | 1.038E-01 | CYP3A4 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| J00-J99: Diseases of the respiratory system | Hay fever | J30 | HRH1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | HRH1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Dementia | F01-F07 | HRH3; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | HRH3; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cough | R05 | HRH1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | HRH3; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | HRH4; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Dry cough | R05 | HRH1; |
| G00-G99: Diseases of the nervous system G00-G99 | Mild to moderate alzheimer disease | G30 | HRH3; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | HRH1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obese insulin-resistant disorders | E11 | HRH3; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | HRH3; |
| G00-G99: Diseases of the nervous system G00-G99 | Narcolepsy | G47.4 | HRH3; |
| H00-H59: Diseases of the eye and adnexa | Ocular allergy | H00-H59 | HRH1; |
| NA: NA | Vasomotor rhinitis | NA | HRH1; |
| NA: NA | Meniere's disease | NA | HRH1; |
| NA: NA | Itching | NA | HRH1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4; HRH1; HRH3; |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | HRH1; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | HRH1; HRH3; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | HRH1; |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | HRH3; |
| NA: NA | Coughs | NA | HRH1; |
| NA: NA | Vomiting | NA | HRH1; |
| NA: NA | Vertigo's disease | NA | HRH1; |
| H60-H95: Diseases of the ear and mastoid process | Vertigo meniere's disease | H81, H81.0, R42 | HRH1; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | HRH1; |
| NA: NA | Hypersensitivity reactions | NA | HRH1; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Nausea | R11 | HRH1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Attention deficit hyperactivity disorder | F90 | HRH3; |
| NA: NA | Perennial and seasonal allergic rhinitis | NA | HRH1; |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | HRH1; |
| NA: NA | Respiratory allergies | NA | HRH1; |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | HRH3; |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | HRH1; HRH4; |
| NA: NA | Urticaria | NA | HRH1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | HRH1; HRH3; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | HRH3; |
| J00-J99: Diseases of the respiratory system | Seasonal and perennial allergic rhinitis and vasomotor rhinitis | J30 | HRH1; |
| J00-J99: Diseases of the respiratory system | Nasal congestion | J34.89 | HRH1; |
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | HRH1; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | HRH4; |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; HRH1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Sleep disorders | F51, G47 | HRH1; HRH3; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
| NA: NA | Morning sickness | NA | HRH1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Eating disorder | E66, F50, I10-I16, I50 | HRH3; |
| NA: NA | Common cold | NA | HRH1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | HRH3; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Excessive daytime sleepiness | F51.1, G47.1 | HRH3; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Musculoskeletal pain | R52, G89 | HRH3; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Anesthesia | R20.0 | HRH1; |
| NA: NA | Allergic disorders | NA | HRH1; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Allergic skin disorders | L00-L99 | HRH1; |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | HRH3; |
| C00-D49: Neoplasms | Allergic conjunctivitis | C91.0, H10, H10.45, T78.4 | HRH1; |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | HRH1; HRH3; HRH4; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | HRH3; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
