Plant Name: Iris tectorum
Taxonomic Information:
Plant ID: NPO14417
Plant Latin Name: Iris tectorum
Taxonomy Genus: Iris
Taxonomy Family: Iridaceae
Plant External Links:
NCBI TaxonomyDB:
114617
Plant-of-the-World-Online:
439168-1
Used in Medicines:
Unknown.
Geographical Distribution:
Italy; South Africa; China; Japan
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TDP1; | |
| EGFR; | |
| PPARA; | |
| TLR2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Protein Kinase | EGFR | Epidermal growth factor receptor erbB1 | P00533 | CHEMBL203 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0050727; regulation of inflammatory response | 3.169E-05 | 2.505E-01 | EGFR, PPARA, TLR2 |
| BP | GO:0007610; behavior | GO:0007610; behavior | 8.511E-05 | 2.505E-01 | EGFR, PPARA, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 9.363E-05 | 2.505E-01 | EGFR, PPARA |
| BP | GO:0051179; localization | GO:0042307; positive regulation of protein import into nucleus | 1.519E-04 | 2.505E-01 | EGFR, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0009725; response to hormone | 1.548E-04 | 2.505E-01 | EGFR, PPARA, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0009628; response to abiotic stimulus | 5.415E-04 | 2.505E-01 | EGFR, PPARA, TLR2 |
| MF | Unclassified; | GO:0032403; protein complex binding | 2.693E-04 | 2.505E-01 | EGFR, PPARA, TLR2 |
| MF | GO:0005488; binding | GO:0003690; double-stranded DNA binding | 3.039E-04 | 2.505E-01 | EGFR, PPARA, TDP1 |
| MF | GO:0005488; binding | GO:0019902; phosphatase binding | 4.251E-04 | 2.505E-01 | EGFR, PPARA |
| MF | GO:0005488; binding | GO:0044877; macromolecular complex binding | 5.164E-04 | 2.505E-01 | EGFR, PPARA, TLR2 |
| MF | GO:0060089; molecular transducer activity | GO:0001875; lipopolysaccharide receptor activity | 1.035E-03 | 2.877E-01 | TLR2 |
| CC | GO:0016020; membrane | GO:0045121; membrane raft | 1.348E-03 | 2.969E-01 | EGFR, TLR2 |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 1.626E-03 | 3.135E-01 | EGFR, TLR2 |
| CC | Unclassified; | GO:0106003; amyloid-beta complex | 2.276E-03 | 3.521E-01 | TLR2 |
| CC | GO:0044464; cell part | GO:0009986; cell surface | 4.542E-03 | 4.607E-01 | EGFR, TLR2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 2.611E-04 | 1.384E-02 | PPARA, EGFR |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 6.069E-04 | 1.608E-02 | EGFR, TLR2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 1.700E-03 | 3.004E-02 | EGFR, TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.333E-02 | 3.581E-02 | EGFR |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 1.413E-02 | 3.581E-02 | EGFR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.393E-02 | 3.581E-02 | PPARA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 1.452E-02 | 3.581E-02 | TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.768E-02 | 3.581E-02 | EGFR |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04012 | ErbB signaling pathway | 1.729E-02 | 3.581E-02 | EGFR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.373E-02 | 3.581E-02 | PPARA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
