CMAUP Plant Collective Molecular Activities

Plant Name: Dioscorea nipponica

Taxonomic Information:

Plant ID: NPO14409
Plant Latin Name: Dioscorea nipponica
Taxonomy Genus: Dioscorea
Taxonomy Family: Dioscoreaceae

Plant External Links:

NCBI TaxonomyDB: 64700
Plant-of-the-World-Online: 318323-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Japan; China; Russia; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	TAAR1;
Hydrolase	GAA;
Enzyme_unclassified	HKDC1; ALOX15; USP2;
Lyase	CA2; CA7; CA5A; CA4; CA6; CA12; CA9; CA1; CA5B; CA14;
Lysine demethylase	KDM4E;
SLC superfamily of solute carriers	SLCO1B3;
Unclassified	MAPT; HTT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	HKDC1	Putative hexokinase HKDC1	Q2TB90	CHEMBL1741200
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
Small molecule receptor (family A GPCR)	TAAR1	Trace amine-associated receptor 1	Q96RJ0	CHEMBL5857
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.390E-08	1.341E-04	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.314E-28	1.157E-23	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.375E-06	3.868E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.326E-22	4.709E-18	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.647E-20	1.441E-16	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.684E-05	1.667E-02	CA1, CA2
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	4.383E-05	3.976E-02	CA2, CA4, CA9, SLCO1B3
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	5.039E-05	4.389E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.428E-27	8.497E-26	CA12, CA1, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.622E-04	3.927E-03	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.191E-04	3.927E-03	CYP1A2, ALOX15
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1.563E-03	9.773E-03	GAA, HKDC1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	4.487E-04	3.927E-03	GAA, HKDC1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.675E-03	9.773E-03	CYP1A2, CYP19A1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.498E-03	1.249E-02	CA2, SLCO1B3
Unclassified	Unclassified	hsa01100	Metabolic pathways	7.999E-03	2.800E-02	GAA, HKDC1, CYP1A2, ALOX15, CYP19A1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	5.240E-03	2.038E-02	CYP1A2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00524	Butirosin and neomycin biosynthesis	5.240E-03	2.038E-02	HKDC1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases