Plant ID: NPO14381
Plant Latin Name: Swertia pseudochinensis
Taxonomy Genus: Swertia
Taxonomy Family: Gentianaceae
NCBI TaxonomyDB:
676131
Plant-of-the-World-Online:
n.a.
China
ALPL; RECQL; TDP1; ALOX12; AKR1B1; HSD17B10; ALOX15; APEX1; POLB; | |
GAA; ACHE; | |
CDK2; CDK6; | |
CA2; CA12; CA9; CA1; CA14; CA5A; CA3; CA7; CA6; | |
MAOA; XDH; | |
BACE1; | |
NFKB1; | |
ABCG2; ABCC1; | |
MAPT; |
Cytochrome P450 Enzymes: | CYP19A1; |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
Protein Kinase | CDK2 | Cyclin-dependent kinase 2 | P24941 | CHEMBL301 |
Protein Kinase | CDK6 | Cyclin-dependent kinase 6 | Q00534 | CHEMBL2508 |
Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 2.332E-06 | 2.418E-03 | APEX1, POLB |
BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 2.332E-06 | 2.418E-03 | ALOX12, ALOX15 |
MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 2.332E-06 | 2.418E-03 | ALOX12, ALOX15 |
BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 5.764E-06 | 5.073E-03 | AKR1B1, ALOX12, ALOX15, APEX1, CYP19A1, GAA, HSD17B10, MAOA, XDH |
BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 6.989E-06 | 5.073E-03 | CA2, CA7 |
MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 6.989E-06 | 5.073E-03 | ALOX12, ALOX15 |
MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 6.989E-06 | 5.073E-03 | ALOX12, ALOX15 |
BP | GO:0009987; cellular process | GO:0033554; cellular response to stress | 9.882E-06 | 6.941E-03 | AKR1B1, ALOX15, APEX1, CA2, CA9, CDK2, MAPT, NFKB1, POLB, RECQL, TDP1 |
MF | GO:0003824; catalytic activity | GO:0016491; oxidoreductase activity | 1.119E-05 | 7.616E-03 | AKR1B1, ALOX12, ALOX15, APEX1, CYP19A1, HSD17B10, MAOA, XDH |
BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 1.476E-05 | 9.180E-03 | ABCC1, ALOX12, ALOX15 |
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 6.914E-23 | 1.506E-18 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 9.519E-18 | 6.909E-14 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.587E-16 | 1.562E-12 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 2.451E-22 | 2.475E-20 | CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14 |
Unclassified | Unclassified | hsa01100 | Metabolic pathways | 5.697E-05 | 2.877E-03 | MAOA, GAA, ALOX15, AKR1B1, ALPL, ALOX12, CYP19A1, HSD17B10, XDH |
09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 2.384E-04 | 7.236E-03 | POLB, CDK6, CDK2, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 2.866E-04 | 7.236E-03 | CDK6, CDK2, NFKB1 |
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 6.217E-04 | 1.256E-02 | MAOA, ALOX15, ALOX12 |
09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 1.092E-03 | 1.409E-02 | CDK6, CDK2, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 1.339E-03 | 1.503E-02 | CDK6, CDK2, NFKB1 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 9.218E-04 | 1.409E-02 | GAA, AKR1B1 |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.116E-03 | 1.409E-02 | POLB, APEX1 |
09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 1.979E-03 | 1.837E-02 | ABCC1, ABCG2 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA; |
G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA; |
C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; ACHE; |
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE; |
K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA; |
G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | MAOA; |
N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE; |
A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA; |
H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | MAOA; |
C00-D49: Neoplasms | Ocular cancer | C69 | APEX1; |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; |
NA: NA | Upper abdominal bloating | NA | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE; MAOA; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE; |
H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ACHE; |
A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE; MAOA; |
G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; MAOA; |