CMAUP Plant Collective Molecular Activities

Plant Name: Artemisia cina

Taxonomic Information:

Plant ID: NPO14354
Plant Latin Name: Artemisia cina
Taxonomy Genus: Artemisia
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Indonesia; India

Traditional Medicine System:

Ayurveda

Medicinal Functions:

Digestive; Febrifuge; Homeopathy; Vermifuge

Geographical Distribution:

Indonesia; India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1; FFAR1; FFAR4; HCAR2;
Enzyme_unclassified	RECQL; ADK; HSD17B2; ALOX15;
Lyase	CA2; CA12; CA7;
Oxidoreductase	TYR;
Transcription Factor	AHR;
Unclassified	LMNA; FABP3; FABP4;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	7.617E-08	4.653E-04	ADORA1, ADORA2A, CYP1A1, CYP1B1, FFAR1, FFAR4, HCAR2, HSD17B2
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	5.145E-08	4.653E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	1.233E-07	5.369E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.760E-07	6.387E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	4.185E-07	1.123E-03	ADORA2A, CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.647E-07	1.319E-03	CA12, CA2, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.934E-06	3.008E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.571E-06	3.294E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.571E-06	3.294E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.066E-06	3.688E-03	CA2, CA7
MF	GO:0005488; binding	GO:0005504; fatty acid binding	4.234E-06	3.688E-03	FABP3, FABP4, FFAR4
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	4.066E-06	3.688E-03	ADORA1, ADORA2A
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	8.126E-06	5.362E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.026E-05	6.385E-03	CA12, CA2, CA7
BP	GO:0008152; metabolic process	GO:0016042; lipid catabolic process	1.408E-05	8.026E-03	ADORA1, CYP1A2, CYP1B1, FABP3, FABP4
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	1.437E-05	8.026E-03	CA2, CYP1A1, CYP1A2, FABP3, FFAR1, HSD17B2, TYR
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	1.624E-05	8.840E-03	ADORA1, ADORA2A, AHR, ALOX15, CA2, CYP1A1, CYP1A2, CYP1B1, HSD17B2, LMNA, SMN1, SMN2, TYR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.410E-07	1.833E-05	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.277E-05	1.745E-04	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.514E-05	2.576E-04	HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.939E-07	1.833E-05	CA12, CA2, CA7
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.840E-05	6.429E-04	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.109E-04	7.577E-04	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.484E-03	7.604E-03	HCAR2, ADORA2A, ADORA1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.261E-03	9.271E-03	HSD17B2, CYP1A2, ALOX15, CYP1A1, ADK, TYR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.876E-03	8.546E-03	FABP4, ADORA1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.040E-04	2.952E-03	CYP1A2, ALOX15
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.518E-03	9.385E-03	CYP1A2, CYP1A1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.832E-03	9.676E-03	FABP3, FABP4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	HIV infections	NA	AHR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HCAR2; FFAR1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Melanoma	C43	TYR;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA1; ADORA2A; ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADORA2A; ADK;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA1; ADORA2A;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1; HCAR2;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1; FFAR1;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A; HCAR2;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HCAR2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases