CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; CNR2;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	FAAH; BLM; GLA; ALDH1A1;
Transient receptor potential channel	TRPV1;
Transcription Factor	NFKB1;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253

Showing 1 to 10 of 12 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	6.403E-09	4.647E-05	CNR1, CNR2, GLA
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	2.121E-06	6.510E-03	CNR1, CNR2
BP	GO:0002376; immune system process	GO:0033004; negative regulation of mast cell activation	1.940E-05	3.840E-02	CNR1, CNR2
BP	GO:0050896; response to stimulus	GO:0043279; response to alkaloid	2.158E-05	3.898E-02	BLM, CNR1, TRPV1
BP	GO:0065007; biological regulation	GO:0045759; negative regulation of action potential	2.327E-05	3.898E-02	CNR1, CNR2
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	1.061E-06	3.851E-03	CNR1, CNR2

Showing 1 to 6 of 6 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.633E-05	1.208E-03	CNR2, CNR1, TRPV1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	6.406E-02	9.844E-02	NFKB1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	8.014E-04	2.965E-02	SLCO1B1, SLCO1B3
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.612E-03	3.977E-02	FAAH, CNR1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	5.498E-02	9.844E-02	NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	6.519E-02	9.844E-02	CYP2C19
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	5.041E-02	9.844E-02	NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	4.410E-02	9.844E-02	NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	6.066E-02	9.844E-02	NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	6.349E-02	9.844E-02	NFKB1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	CNR1; TRPV1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Ovarian cancer	C56	CNR1;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	TRPV1;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	CNR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	CNR1;

Showing 1 to 10 of 42 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Agave aurea

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities